Dual inhibition of BRD4 and PI3K-AKT by SF2523 suppresses human renal cell carcinoma cell growth

Bromodomain-containing protein 4 (BRD4) and PI3K-AKT are both important for renal cell carcinoma (RCC) development and progression. SF2523 is a BRD4 and PI3K-AKT dual inhibitor. The present study demonstrated that SF2523 was cytotoxic and anti-proliferative to established RCC cell lines (786-O and A...

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Detalles Bibliográficos
Autores principales: Zhu, Hua, Mao, Jia-Hui, Wang, Yin, Gu, Dong-Hua, Pan, Xiao-Dong, Shan, Yuxi, Zheng, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716743/
https://www.ncbi.nlm.nih.gov/pubmed/29228703
http://dx.doi.org/10.18632/oncotarget.21432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716743/
https://www.ncbi.nlm.nih.gov/pubmed/29228703
http://dx.doi.org/10.18632/oncotarget.21432

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