Somatic PRDM2 c.4467delA mutations in colorectal cancers control histone methylation and tumor growth

The chromatin modifier PRDM2/RIZ1 is inactivated by mutation in several forms of cancer and is a putative tumor suppressor gene. Frameshift mutations in the C-terminal region of PRDM2, affecting (A)8 or (A)9 repeats within exon 8, are found in one third of colorectal cancers with microsatellite inst...

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Detalles Bibliográficos
Autores principales: Pandzic, Tatjana, Rendo, Veronica, Lim, Jinyeong, Larsson, Chatarina, Larsson, Jimmy, Stoimenov, Ivaylo, Kundu, Snehangshu, Ali, Muhammad Akhtar, Hellström, Mats, He, Liqun, Lindroth, Anders M., Sjöblom, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716757/
https://www.ncbi.nlm.nih.gov/pubmed/29228717
http://dx.doi.org/10.18632/oncotarget.21713

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