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Distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in HBV high prevalent region

Splenic marginal zone lymphoma (SMZL) is a rare indolent B-cell neoplasm with hepatitis virus supposed to involve in the pathogenesis. The characteristics of SMZL derived from Caucasia population and high hepatitis C virus (HCV) infection region have been widely investigated, but few was reported in...

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Autores principales: Yi, Shuhua, Yan, Yuting, Xiong, Wenjie, Lv, Rui, Yu, Zhen, Liu, Wei, Liu, Enbin, Li, Heng, Liu, Huimin, Li, Zengjun, An, Gang, Xu, Yan, Ru, Kun, Zou, Dehui, Qiu, Lugui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716765/
https://www.ncbi.nlm.nih.gov/pubmed/29228725
http://dx.doi.org/10.18632/oncotarget.21931
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author Yi, Shuhua
Yan, Yuting
Xiong, Wenjie
Lv, Rui
Yu, Zhen
Liu, Wei
Liu, Enbin
Li, Heng
Liu, Huimin
Li, Zengjun
An, Gang
Xu, Yan
Ru, Kun
Zou, Dehui
Qiu, Lugui
author_facet Yi, Shuhua
Yan, Yuting
Xiong, Wenjie
Lv, Rui
Yu, Zhen
Liu, Wei
Liu, Enbin
Li, Heng
Liu, Huimin
Li, Zengjun
An, Gang
Xu, Yan
Ru, Kun
Zou, Dehui
Qiu, Lugui
author_sort Yi, Shuhua
collection PubMed
description Splenic marginal zone lymphoma (SMZL) is a rare indolent B-cell neoplasm with hepatitis virus supposed to involve in the pathogenesis. The characteristics of SMZL derived from Caucasia population and high hepatitis C virus (HCV) infection region have been widely investigated, but few was reported in the Eastern population with HBV prevalent region. We analyzed the clinical characteristics, cytogenetic aberrations and prognostic factors in 160 SMZL patients from China. 25 patients (16%) were HBsAg-positive and 54 (34%) patients with resolved HBV infection. IGH gene usage was analyzed in 39 patients. The preferential usages of IGHV genes were IGHV1-2 (26%), followed by IGHV4-34 (18%) and IGHV2-70 (10%). The patients with HBV infection presented biased IGHV-D-J rearrangements and mutational status. Using three independent factors hemoglobin level, HBsAg positivity and complex karyotype, we developed a new hierarchical prognostic model, which showed a better c-index than the previously reported IIL and HPLL scoring systems in SMZL. In conclusion, SMZL in HBV prevalent region have unique clinical and biological characteristics and new prognostic scoring model should be adopted in this population.
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spelling pubmed-57167652017-12-08 Distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in HBV high prevalent region Yi, Shuhua Yan, Yuting Xiong, Wenjie Lv, Rui Yu, Zhen Liu, Wei Liu, Enbin Li, Heng Liu, Huimin Li, Zengjun An, Gang Xu, Yan Ru, Kun Zou, Dehui Qiu, Lugui Oncotarget Research Paper Splenic marginal zone lymphoma (SMZL) is a rare indolent B-cell neoplasm with hepatitis virus supposed to involve in the pathogenesis. The characteristics of SMZL derived from Caucasia population and high hepatitis C virus (HCV) infection region have been widely investigated, but few was reported in the Eastern population with HBV prevalent region. We analyzed the clinical characteristics, cytogenetic aberrations and prognostic factors in 160 SMZL patients from China. 25 patients (16%) were HBsAg-positive and 54 (34%) patients with resolved HBV infection. IGH gene usage was analyzed in 39 patients. The preferential usages of IGHV genes were IGHV1-2 (26%), followed by IGHV4-34 (18%) and IGHV2-70 (10%). The patients with HBV infection presented biased IGHV-D-J rearrangements and mutational status. Using three independent factors hemoglobin level, HBsAg positivity and complex karyotype, we developed a new hierarchical prognostic model, which showed a better c-index than the previously reported IIL and HPLL scoring systems in SMZL. In conclusion, SMZL in HBV prevalent region have unique clinical and biological characteristics and new prognostic scoring model should be adopted in this population. Impact Journals LLC 2017-10-19 /pmc/articles/PMC5716765/ /pubmed/29228725 http://dx.doi.org/10.18632/oncotarget.21931 Text en Copyright: © 2017 Yi et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Yi, Shuhua
Yan, Yuting
Xiong, Wenjie
Lv, Rui
Yu, Zhen
Liu, Wei
Liu, Enbin
Li, Heng
Liu, Huimin
Li, Zengjun
An, Gang
Xu, Yan
Ru, Kun
Zou, Dehui
Qiu, Lugui
Distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in HBV high prevalent region
title Distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in HBV high prevalent region
title_full Distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in HBV high prevalent region
title_fullStr Distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in HBV high prevalent region
title_full_unstemmed Distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in HBV high prevalent region
title_short Distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in HBV high prevalent region
title_sort distinct clinical characteristics draw a new prognostic model for splenic marginal zone lymphoma in hbv high prevalent region
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716765/
https://www.ncbi.nlm.nih.gov/pubmed/29228725
http://dx.doi.org/10.18632/oncotarget.21931
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