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The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis
PURPOSE: A variety of studies have observed that the single nucleotide polymorphisms (SNPs) matrix metalloproteinase-9 (MMP-9) gene may be associated with the risk of gastric cancer(GC), and a cytosine (C) to thymine (T) mutation at the -1562 site of the MMP-9 gene promoter is reported to be closely...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716787/ https://www.ncbi.nlm.nih.gov/pubmed/29228747 http://dx.doi.org/10.18632/oncotarget.20931 |
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author | Peng, Ziheng Jia, Jinhai Gong, Wenjian Gao, Xuehan Ma, Peiru Jin, Zhucheng Fan, Yue Li, Yanchu Zhang, Xiaolin |
author_facet | Peng, Ziheng Jia, Jinhai Gong, Wenjian Gao, Xuehan Ma, Peiru Jin, Zhucheng Fan, Yue Li, Yanchu Zhang, Xiaolin |
author_sort | Peng, Ziheng |
collection | PubMed |
description | PURPOSE: A variety of studies have observed that the single nucleotide polymorphisms (SNPs) matrix metalloproteinase-9 (MMP-9) gene may be associated with the risk of gastric cancer(GC), and a cytosine (C) to thymine (T) mutation at the -1562 site of the MMP-9 gene promoter is reported to be closely related to the susceptibility. However, because of the conflicting results of these studies, we undertook a systematic meta-analysis to assess the association between the SNPs and the risk of gastric cancer. MATERIALS AND METHODS: A computerised literature search was conducted within the databases of PubMed, EMBASE, and ISI Web of Knowledge for studies on the genetic association of MMP-9-1562C/T and gastric cancer published from 2004 to 2015. The pooled odds ratio (OR) and 95% confidence intervals (CI) were estimated for each genotype using the dominant, recessive, co-dominant, and allelic models of the matrix metalloproteinase 9. RESULTS: Our analysis indicated a significant association of MMP-9-1562C/T with gastric cancer (dominant model [CT+TT/CC]: OR = 1.121, 95% CI = 0.965–1.304; recessive model [CC+CT/TT]: OR = 1.663, 95% CI = 1.148–2.408; co-dominant model [TT/CC]: OR = 1.666, 95% CI = 1.127–2.461; [CT/CC]: OR = 1.078, 95% CI = 0.923–1.259; allelic model [T/C]: OR = 1.150, 95% CI =1.014–1.304). CONCLUSIONS: Our meta-analysis results demonstrated that MMP-9-1562C/T promoter polymorphisms increase the risk of developing gastric cancer. |
format | Online Article Text |
id | pubmed-5716787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57167872017-12-08 The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis Peng, Ziheng Jia, Jinhai Gong, Wenjian Gao, Xuehan Ma, Peiru Jin, Zhucheng Fan, Yue Li, Yanchu Zhang, Xiaolin Oncotarget Meta-Analysis PURPOSE: A variety of studies have observed that the single nucleotide polymorphisms (SNPs) matrix metalloproteinase-9 (MMP-9) gene may be associated with the risk of gastric cancer(GC), and a cytosine (C) to thymine (T) mutation at the -1562 site of the MMP-9 gene promoter is reported to be closely related to the susceptibility. However, because of the conflicting results of these studies, we undertook a systematic meta-analysis to assess the association between the SNPs and the risk of gastric cancer. MATERIALS AND METHODS: A computerised literature search was conducted within the databases of PubMed, EMBASE, and ISI Web of Knowledge for studies on the genetic association of MMP-9-1562C/T and gastric cancer published from 2004 to 2015. The pooled odds ratio (OR) and 95% confidence intervals (CI) were estimated for each genotype using the dominant, recessive, co-dominant, and allelic models of the matrix metalloproteinase 9. RESULTS: Our analysis indicated a significant association of MMP-9-1562C/T with gastric cancer (dominant model [CT+TT/CC]: OR = 1.121, 95% CI = 0.965–1.304; recessive model [CC+CT/TT]: OR = 1.663, 95% CI = 1.148–2.408; co-dominant model [TT/CC]: OR = 1.666, 95% CI = 1.127–2.461; [CT/CC]: OR = 1.078, 95% CI = 0.923–1.259; allelic model [T/C]: OR = 1.150, 95% CI =1.014–1.304). CONCLUSIONS: Our meta-analysis results demonstrated that MMP-9-1562C/T promoter polymorphisms increase the risk of developing gastric cancer. Impact Journals LLC 2017-09-15 /pmc/articles/PMC5716787/ /pubmed/29228747 http://dx.doi.org/10.18632/oncotarget.20931 Text en Copyright: © 2017 Peng et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Meta-Analysis Peng, Ziheng Jia, Jinhai Gong, Wenjian Gao, Xuehan Ma, Peiru Jin, Zhucheng Fan, Yue Li, Yanchu Zhang, Xiaolin The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis |
title | The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis |
title_full | The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis |
title_fullStr | The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis |
title_full_unstemmed | The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis |
title_short | The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis |
title_sort | association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716787/ https://www.ncbi.nlm.nih.gov/pubmed/29228747 http://dx.doi.org/10.18632/oncotarget.20931 |
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