HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia

Philadelphia chromosome-positive (Ph+) B-cell precursor acute lymphoblastic leukemia (ALL) expressing BCR-ABL1 oncoprotein is a major subclass of ALL with poor prognosis. BCR-ABL1-expressing leukemic cells are highly dependent on double-strand break (DSB) repair signals for their survival. Here we r...

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Detalles Bibliográficos
Autores principales: Tharkar-Promod, S, Johnson, D P, Bennett, S E, Dennis, E M, Banowsky, B G, Jones, S S, Shearstone, J R, Quayle, S N, Min, C, Jarpe, M, Mosbruger, T, Pomicter, A D, Miles, R R, Chen, W Y, Bhalla, K N, Zweidler-McKay, P A, Shrieve, D C, Deininger, M W, Chandrasekharan, M B, Bhaskara, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716937/
https://www.ncbi.nlm.nih.gov/pubmed/28579617
http://dx.doi.org/10.1038/leu.2017.174

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