Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer

Cdc7-Dbf4 kinase plays a key role in the initiation of DNA replication and contributes to the replication stress in cancer. The activity of human Cdc7-Dbf4 kinase remains active and acts as an effector of checkpoint under replication stress. However, the downstream targets of Cdc7-Dbf4 contributed t...

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Detalles Bibliográficos
Autores principales: Cheng, An Ning, Fan, Chi-Chen, Lo, Yu-Kang, Kuo, Cheng-Liang, Wang, Hui-Chun, Lien, I.-Hsin, Lin, Shu-Yu, Chen, Chung-Hsing, Jiang, Shih Sheng, Chang, I.-Shou, Juan, Hsueh-Fen, Lyu, Ping-Chiang, Lee, Alan Yueh-Luen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717001/
https://www.ncbi.nlm.nih.gov/pubmed/29209046
http://dx.doi.org/10.1038/s41598-017-17126-2

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