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A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication

Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity. The mechanism of interactions between PNNs and neurons remain uncharacterized. In this review,...

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Detalles Bibliográficos
Autores principales: van 't Spijker, Heleen M., Kwok, Jessica C. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717013/
https://www.ncbi.nlm.nih.gov/pubmed/29249944
http://dx.doi.org/10.3389/fnint.2017.00033
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author van 't Spijker, Heleen M.
Kwok, Jessica C. F.
author_facet van 't Spijker, Heleen M.
Kwok, Jessica C. F.
author_sort van 't Spijker, Heleen M.
collection PubMed
description Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity. The mechanism of interactions between PNNs and neurons remain uncharacterized. In this review, we pose the question: how do PNNs regulate communication to and from neurons? We provide an overview of the current knowledge on PNNs with a focus on the cellular interactions. PNNs ensheath a subset of the neuronal population with distinct molecular aspects in different areas of the CNS. PNNs control neuronal communication through molecular interactions involving specific components of the PNNs. This review proposes that the PNNs are an integral part of neurons, crucial for the regulation of plasticity in the CNS.
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spelling pubmed-57170132017-12-15 A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication van 't Spijker, Heleen M. Kwok, Jessica C. F. Front Integr Neurosci Neuroscience Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity. The mechanism of interactions between PNNs and neurons remain uncharacterized. In this review, we pose the question: how do PNNs regulate communication to and from neurons? We provide an overview of the current knowledge on PNNs with a focus on the cellular interactions. PNNs ensheath a subset of the neuronal population with distinct molecular aspects in different areas of the CNS. PNNs control neuronal communication through molecular interactions involving specific components of the PNNs. This review proposes that the PNNs are an integral part of neurons, crucial for the regulation of plasticity in the CNS. Frontiers Media S.A. 2017-12-01 /pmc/articles/PMC5717013/ /pubmed/29249944 http://dx.doi.org/10.3389/fnint.2017.00033 Text en Copyright © 2017 van 't Spijker and Kwok. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
van 't Spijker, Heleen M.
Kwok, Jessica C. F.
A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
title A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
title_full A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
title_fullStr A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
title_full_unstemmed A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
title_short A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
title_sort sweet talk: the molecular systems of perineuronal nets in controlling neuronal communication
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717013/
https://www.ncbi.nlm.nih.gov/pubmed/29249944
http://dx.doi.org/10.3389/fnint.2017.00033
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