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A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity. The mechanism of interactions between PNNs and neurons remain uncharacterized. In this review,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717013/ https://www.ncbi.nlm.nih.gov/pubmed/29249944 http://dx.doi.org/10.3389/fnint.2017.00033 |
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author | van 't Spijker, Heleen M. Kwok, Jessica C. F. |
author_facet | van 't Spijker, Heleen M. Kwok, Jessica C. F. |
author_sort | van 't Spijker, Heleen M. |
collection | PubMed |
description | Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity. The mechanism of interactions between PNNs and neurons remain uncharacterized. In this review, we pose the question: how do PNNs regulate communication to and from neurons? We provide an overview of the current knowledge on PNNs with a focus on the cellular interactions. PNNs ensheath a subset of the neuronal population with distinct molecular aspects in different areas of the CNS. PNNs control neuronal communication through molecular interactions involving specific components of the PNNs. This review proposes that the PNNs are an integral part of neurons, crucial for the regulation of plasticity in the CNS. |
format | Online Article Text |
id | pubmed-5717013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57170132017-12-15 A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication van 't Spijker, Heleen M. Kwok, Jessica C. F. Front Integr Neurosci Neuroscience Perineuronal nets (PNNs) are mesh-like structures, composed of a hierarchical assembly of extracellular matrix molecules in the central nervous system (CNS), ensheathing neurons and regulating plasticity. The mechanism of interactions between PNNs and neurons remain uncharacterized. In this review, we pose the question: how do PNNs regulate communication to and from neurons? We provide an overview of the current knowledge on PNNs with a focus on the cellular interactions. PNNs ensheath a subset of the neuronal population with distinct molecular aspects in different areas of the CNS. PNNs control neuronal communication through molecular interactions involving specific components of the PNNs. This review proposes that the PNNs are an integral part of neurons, crucial for the regulation of plasticity in the CNS. Frontiers Media S.A. 2017-12-01 /pmc/articles/PMC5717013/ /pubmed/29249944 http://dx.doi.org/10.3389/fnint.2017.00033 Text en Copyright © 2017 van 't Spijker and Kwok. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience van 't Spijker, Heleen M. Kwok, Jessica C. F. A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication |
title | A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication |
title_full | A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication |
title_fullStr | A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication |
title_full_unstemmed | A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication |
title_short | A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication |
title_sort | sweet talk: the molecular systems of perineuronal nets in controlling neuronal communication |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717013/ https://www.ncbi.nlm.nih.gov/pubmed/29249944 http://dx.doi.org/10.3389/fnint.2017.00033 |
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