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Major depletion of SOX2(+) stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling
The pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by depleting SOX2(+) cells through diphtheria toxin (DT)-mediated ablation. DT treatment of adult Sox2(CreERT2/+);R26(iDTR/+) mice (after tamoxif...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717068/ https://www.ncbi.nlm.nih.gov/pubmed/29208952 http://dx.doi.org/10.1038/s41598-017-16796-2 |