A comparative study on the characterization of hepatitis B virus quasispecies by clone-based sequencing and third-generation sequencing

Hepatitis B virus (HBV) has a high mutation rate due to the extremely high replication rate and the proofreading deficiency during reverse transcription. The generated variants with genetic heterogeneity are described as viral quasispecies (QS). Clone-based sequencing (CBS) is thought to be the ‘gol...

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Detalles Bibliográficos
Autores principales: Li, Jing, Wang, Mingjie, Yu, Demin, Han, Yue, Yang, Zhitao, Wang, Lei, Zhang, Xinxin, Liu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717089/
https://www.ncbi.nlm.nih.gov/pubmed/29116219
http://dx.doi.org/10.1038/emi.2017.88

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