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MiR-211 is essential for adult cone photoreceptor maintenance and visual function
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that play an important role in the control of fundamental biological processes in both physiological and pathological conditions. Their function in retinal cells is just beginning to be elucidated, and a few have been foun...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717140/ https://www.ncbi.nlm.nih.gov/pubmed/29209045 http://dx.doi.org/10.1038/s41598-017-17331-z |
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author | Barbato, Sara Marrocco, Elena Intartaglia, Daniela Pizzo, Mariateresa Asteriti, Sabrina Naso, Federica Falanga, Danila Bhat, Rajeshwari S. Meola, Nicola Carissimo, Annamaria Karali, Marianthi Prosser, Haydn M. Cangiano, Lorenzo Surace, Enrico Maria Banfi, Sandro Conte, Ivan |
author_facet | Barbato, Sara Marrocco, Elena Intartaglia, Daniela Pizzo, Mariateresa Asteriti, Sabrina Naso, Federica Falanga, Danila Bhat, Rajeshwari S. Meola, Nicola Carissimo, Annamaria Karali, Marianthi Prosser, Haydn M. Cangiano, Lorenzo Surace, Enrico Maria Banfi, Sandro Conte, Ivan |
author_sort | Barbato, Sara |
collection | PubMed |
description | MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that play an important role in the control of fundamental biological processes in both physiological and pathological conditions. Their function in retinal cells is just beginning to be elucidated, and a few have been found to play a role in photoreceptor maintenance and function. MiR-211 is one of the most abundant miRNAs in the developing and adult eye. However, its role in controlling vertebrate visual system development, maintenance and function so far remain incompletely unexplored. Here, by targeted inactivation in a mouse model, we identify a critical role of miR-211 in cone photoreceptor function and survival. MiR-211 knockout (−/−) mice exhibited a progressive cone dystrophy accompanied by significant alterations in visual function. Transcriptome analysis of the retina from miR-211−/− mice during cone degeneration revealed significant alteration of pathways related to cell metabolism. Collectively, this study highlights for the first time the impact of miR-211 function in the retina and significantly contributes to unravelling the role of specific miRNAs in cone photoreceptor function and survival. |
format | Online Article Text |
id | pubmed-5717140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57171402017-12-08 MiR-211 is essential for adult cone photoreceptor maintenance and visual function Barbato, Sara Marrocco, Elena Intartaglia, Daniela Pizzo, Mariateresa Asteriti, Sabrina Naso, Federica Falanga, Danila Bhat, Rajeshwari S. Meola, Nicola Carissimo, Annamaria Karali, Marianthi Prosser, Haydn M. Cangiano, Lorenzo Surace, Enrico Maria Banfi, Sandro Conte, Ivan Sci Rep Article MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that play an important role in the control of fundamental biological processes in both physiological and pathological conditions. Their function in retinal cells is just beginning to be elucidated, and a few have been found to play a role in photoreceptor maintenance and function. MiR-211 is one of the most abundant miRNAs in the developing and adult eye. However, its role in controlling vertebrate visual system development, maintenance and function so far remain incompletely unexplored. Here, by targeted inactivation in a mouse model, we identify a critical role of miR-211 in cone photoreceptor function and survival. MiR-211 knockout (−/−) mice exhibited a progressive cone dystrophy accompanied by significant alterations in visual function. Transcriptome analysis of the retina from miR-211−/− mice during cone degeneration revealed significant alteration of pathways related to cell metabolism. Collectively, this study highlights for the first time the impact of miR-211 function in the retina and significantly contributes to unravelling the role of specific miRNAs in cone photoreceptor function and survival. Nature Publishing Group UK 2017-12-05 /pmc/articles/PMC5717140/ /pubmed/29209045 http://dx.doi.org/10.1038/s41598-017-17331-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Barbato, Sara Marrocco, Elena Intartaglia, Daniela Pizzo, Mariateresa Asteriti, Sabrina Naso, Federica Falanga, Danila Bhat, Rajeshwari S. Meola, Nicola Carissimo, Annamaria Karali, Marianthi Prosser, Haydn M. Cangiano, Lorenzo Surace, Enrico Maria Banfi, Sandro Conte, Ivan MiR-211 is essential for adult cone photoreceptor maintenance and visual function |
title | MiR-211 is essential for adult cone photoreceptor maintenance and visual function |
title_full | MiR-211 is essential for adult cone photoreceptor maintenance and visual function |
title_fullStr | MiR-211 is essential for adult cone photoreceptor maintenance and visual function |
title_full_unstemmed | MiR-211 is essential for adult cone photoreceptor maintenance and visual function |
title_short | MiR-211 is essential for adult cone photoreceptor maintenance and visual function |
title_sort | mir-211 is essential for adult cone photoreceptor maintenance and visual function |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717140/ https://www.ncbi.nlm.nih.gov/pubmed/29209045 http://dx.doi.org/10.1038/s41598-017-17331-z |
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