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Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo

Sphingosine-1-phospate is a potent bioactive lipid metabolite that regulates cancer progression. Because sphingosine kinase 1 and sphingosine kinase 2 (SPHK 1/2) are both essential for sphingosine-1-phospate production, they could be a therapeutic target in various cancers. Peretinoin, an acyclic re...

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Detalles Bibliográficos
Autores principales:	Funaki, Masaya, Kitabayashi, Juria, Shimakami, Tetsuro, Nagata, Naoto, Sakai, Yuriko, Takegoshi, Kai, Okada, Hikari, Murai, Kazuhisa, Shirasaki, Takayoshi, Oyama, Takeru, Yamashita, Taro, Ota, Tsuguhito, Takuwa, Yoh, Honda, Masao, Kaneko, Shuichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717167/ https://www.ncbi.nlm.nih.gov/pubmed/29208982 http://dx.doi.org/10.1038/s41598-017-17285-2

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