Cargando…
Quantitative trait loci mapping for feed conversion efficiency in crucian carp (Carassius auratus)
QTL is a chromosomal region including single gene or gene clusters that determine a quantitative trait. While feed efficiency is highly important in aquaculture fish, little genetic and genomic progresses have been made for this trait. In this study, we constructed a high-resolution genetic linkage...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717303/ https://www.ncbi.nlm.nih.gov/pubmed/29209087 http://dx.doi.org/10.1038/s41598-017-17269-2 |
_version_ | 1783284117427716096 |
---|---|
author | Pang, Meixia Fu, Beide Yu, Xiaomu Liu, Haiyang Wang, Xinhua Yin, Zhan Xie, Shouqi Tong, Jingou |
author_facet | Pang, Meixia Fu, Beide Yu, Xiaomu Liu, Haiyang Wang, Xinhua Yin, Zhan Xie, Shouqi Tong, Jingou |
author_sort | Pang, Meixia |
collection | PubMed |
description | QTL is a chromosomal region including single gene or gene clusters that determine a quantitative trait. While feed efficiency is highly important in aquaculture fish, little genetic and genomic progresses have been made for this trait. In this study, we constructed a high-resolution genetic linkage map in a full-sib F1 family of crucian carp (Carassius auratus) consisting of 113 progenies with 8,460 SNP markers assigning onto 50 linkage groups (LGs). This genetic map spanned 4,047.824 cM (0.478 cM/marker) and covered 98.76% of the crucian carp genome. 35 chromosome-wide QTL affecting feed conversion efficiency (FCE, 8 QTL), relative growth rate (RGR, 9 QTL), average daily gain (ADG, 13 QTL) and average daily feed intake (ADFI, 5 QTL) were detected on 14 LGs, explaining 14.0–20.9% of the phenotypic variations. In LGs of LG16, LG25, LG36 and LG49, several QTL affecting different traits clustered together at the identical or close regions of the same linkage group. Seven candidate genes, whose biological functions may involve in the energy metabolism, digestion, biosynthesis and signal transduction, were identified from these QTL intervals by comparative genomics analysis. These results provide a basis for elucidating genetic mechanism of feed efficiency and potential marker-assisted selection in crucian carp. |
format | Online Article Text |
id | pubmed-5717303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57173032017-12-08 Quantitative trait loci mapping for feed conversion efficiency in crucian carp (Carassius auratus) Pang, Meixia Fu, Beide Yu, Xiaomu Liu, Haiyang Wang, Xinhua Yin, Zhan Xie, Shouqi Tong, Jingou Sci Rep Article QTL is a chromosomal region including single gene or gene clusters that determine a quantitative trait. While feed efficiency is highly important in aquaculture fish, little genetic and genomic progresses have been made for this trait. In this study, we constructed a high-resolution genetic linkage map in a full-sib F1 family of crucian carp (Carassius auratus) consisting of 113 progenies with 8,460 SNP markers assigning onto 50 linkage groups (LGs). This genetic map spanned 4,047.824 cM (0.478 cM/marker) and covered 98.76% of the crucian carp genome. 35 chromosome-wide QTL affecting feed conversion efficiency (FCE, 8 QTL), relative growth rate (RGR, 9 QTL), average daily gain (ADG, 13 QTL) and average daily feed intake (ADFI, 5 QTL) were detected on 14 LGs, explaining 14.0–20.9% of the phenotypic variations. In LGs of LG16, LG25, LG36 and LG49, several QTL affecting different traits clustered together at the identical or close regions of the same linkage group. Seven candidate genes, whose biological functions may involve in the energy metabolism, digestion, biosynthesis and signal transduction, were identified from these QTL intervals by comparative genomics analysis. These results provide a basis for elucidating genetic mechanism of feed efficiency and potential marker-assisted selection in crucian carp. Nature Publishing Group UK 2017-12-05 /pmc/articles/PMC5717303/ /pubmed/29209087 http://dx.doi.org/10.1038/s41598-017-17269-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Pang, Meixia Fu, Beide Yu, Xiaomu Liu, Haiyang Wang, Xinhua Yin, Zhan Xie, Shouqi Tong, Jingou Quantitative trait loci mapping for feed conversion efficiency in crucian carp (Carassius auratus) |
title | Quantitative trait loci mapping for feed conversion efficiency in crucian carp (Carassius auratus) |
title_full | Quantitative trait loci mapping for feed conversion efficiency in crucian carp (Carassius auratus) |
title_fullStr | Quantitative trait loci mapping for feed conversion efficiency in crucian carp (Carassius auratus) |
title_full_unstemmed | Quantitative trait loci mapping for feed conversion efficiency in crucian carp (Carassius auratus) |
title_short | Quantitative trait loci mapping for feed conversion efficiency in crucian carp (Carassius auratus) |
title_sort | quantitative trait loci mapping for feed conversion efficiency in crucian carp (carassius auratus) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717303/ https://www.ncbi.nlm.nih.gov/pubmed/29209087 http://dx.doi.org/10.1038/s41598-017-17269-2 |
work_keys_str_mv | AT pangmeixia quantitativetraitlocimappingforfeedconversionefficiencyincruciancarpcarassiusauratus AT fubeide quantitativetraitlocimappingforfeedconversionefficiencyincruciancarpcarassiusauratus AT yuxiaomu quantitativetraitlocimappingforfeedconversionefficiencyincruciancarpcarassiusauratus AT liuhaiyang quantitativetraitlocimappingforfeedconversionefficiencyincruciancarpcarassiusauratus AT wangxinhua quantitativetraitlocimappingforfeedconversionefficiencyincruciancarpcarassiusauratus AT yinzhan quantitativetraitlocimappingforfeedconversionefficiencyincruciancarpcarassiusauratus AT xieshouqi quantitativetraitlocimappingforfeedconversionefficiencyincruciancarpcarassiusauratus AT tongjingou quantitativetraitlocimappingforfeedconversionefficiencyincruciancarpcarassiusauratus |