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Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models

Most neurodegenerative disorders are associated with accumulation of disease-relevant proteins. Among them, Huntington disease (HD) is of particular interest because of its monogenetic nature. HD is mainly caused by cytotoxicity of the defective protein encoded by the mutant Huntingtin gene (HTT). T...

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Detalles Bibliográficos
Autores principales:	Yu, Meng, Fu, Yuhua, Liang, Yijiang, Song, Haikun, Yao, Yao, Wu, Peng, Yao, Yuwei, Pan, Yuyin, Wen, Xue, Ma, Lixiang, Hexige, Saiyin, Ding, Yu, Luo, Shouqing, Lu, Boxun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717400/ https://www.ncbi.nlm.nih.gov/pubmed/29151587 http://dx.doi.org/10.1038/cr.2017.113

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