Rare variants of the 3’-5’ DNA exonuclease TREX1 in early onset small vessel stroke

Background: Monoallelic and biallelic mutations in the exonuclease TREX1 cause monogenic small vessel diseases (SVD). Given recent evidence for genetic and pathophysiological overlap between monogenic and polygenic forms of SVD, evaluation of TREX1 in small vessel stroke is warranted. Methods: We se...

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Detalles Bibliográficos
Autores principales: McGlasson, Sarah, Rannikmäe, Kristiina, Bevan, Steven, Logan, Clare, Bicknell, Louise S., Jury, Alexa, Jackson, Andrew P., Markus, Hugh S., Sudlow, Cathie, Hunt, David P.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717473/
https://www.ncbi.nlm.nih.gov/pubmed/29387804
http://dx.doi.org/10.12688/wellcomeopenres.12631.1

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