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Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?

OBJECTIVE: The aim of this observational study was to clarify the link between vitamin D status and metabolic syndrome (MetS) in people with visceral obesity. DESIGN AND METHODS: One hundred ninety-six consecutive patients (152 women; mean age 51 ± 13 years) with visceral obesity (mean body weight 1...

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Autores principales: Piantanida, Eliana, Gallo, Daniela, Veronesi, Giovanni, Dozio, Eugenia, Trotti, Eugenia, Lai, Adriana, Ippolito, Silvia, Sabatino, Jessica, Tanda, Maria Laura, Toniolo, Antonio, Ferrario, Marco, Bartalena, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717541/
https://www.ncbi.nlm.nih.gov/pubmed/29089365
http://dx.doi.org/10.1530/EC-17-0304
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author Piantanida, Eliana
Gallo, Daniela
Veronesi, Giovanni
Dozio, Eugenia
Trotti, Eugenia
Lai, Adriana
Ippolito, Silvia
Sabatino, Jessica
Tanda, Maria Laura
Toniolo, Antonio
Ferrario, Marco
Bartalena, Luigi
author_facet Piantanida, Eliana
Gallo, Daniela
Veronesi, Giovanni
Dozio, Eugenia
Trotti, Eugenia
Lai, Adriana
Ippolito, Silvia
Sabatino, Jessica
Tanda, Maria Laura
Toniolo, Antonio
Ferrario, Marco
Bartalena, Luigi
author_sort Piantanida, Eliana
collection PubMed
description OBJECTIVE: The aim of this observational study was to clarify the link between vitamin D status and metabolic syndrome (MetS) in people with visceral obesity. DESIGN AND METHODS: One hundred ninety-six consecutive patients (152 women; mean age 51 ± 13 years) with visceral obesity (mean body weight 103 ± 20 kg, mean waist circumference (WC) 119 ± 13 cm) were enrolled at the Obesity Outpatient Clinic of the University of Insubria in Varese. Anthropometric measurements were recorded. Laboratory tests, including vitamin D (25(OH)D)), fasting blood glucose (FBG), lipid profile, liver and kidney function tests were assessed. Vitamin D status was defined according to the European Society of Endocrinology guidelines, MetS to the 2009 harmonized definition. RESULTS: An inverse association emerged among 25(OH)D, body mass index (BMI) (P = 0.001) and WC (all P = 0.003). Serum 25(OH)D levels were inversely related to FBG and systolic blood pressure (SBP) (respectively, P = 0.01 and 0.02). Median serum 25(OH)D levels were 13.3 ng/mL (CI 95% 12; 15) in MetS and 16 ng/mL (CI 95% 14; 18) (P = 0.01) in non-MetS patients. Among patients with MetS, lower 25(OH)D concentrations were related to higher risk of hypertension (HT) (odds ratio (OR) 1.7, CI 95%, 0.7;4) and hyperglycemia (IFG)/type 2 diabetes (OR 5.5, CI 95% 2; 14). CONCLUSION: Vitamin D status and MetS are inversely correlated in visceral obesity, particularly with regard to glucose homeostasis and BP. More extensive studies are required to investigate the potential for causality.
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spelling pubmed-57175412017-12-08 Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role? Piantanida, Eliana Gallo, Daniela Veronesi, Giovanni Dozio, Eugenia Trotti, Eugenia Lai, Adriana Ippolito, Silvia Sabatino, Jessica Tanda, Maria Laura Toniolo, Antonio Ferrario, Marco Bartalena, Luigi Endocr Connect Research OBJECTIVE: The aim of this observational study was to clarify the link between vitamin D status and metabolic syndrome (MetS) in people with visceral obesity. DESIGN AND METHODS: One hundred ninety-six consecutive patients (152 women; mean age 51 ± 13 years) with visceral obesity (mean body weight 103 ± 20 kg, mean waist circumference (WC) 119 ± 13 cm) were enrolled at the Obesity Outpatient Clinic of the University of Insubria in Varese. Anthropometric measurements were recorded. Laboratory tests, including vitamin D (25(OH)D)), fasting blood glucose (FBG), lipid profile, liver and kidney function tests were assessed. Vitamin D status was defined according to the European Society of Endocrinology guidelines, MetS to the 2009 harmonized definition. RESULTS: An inverse association emerged among 25(OH)D, body mass index (BMI) (P = 0.001) and WC (all P = 0.003). Serum 25(OH)D levels were inversely related to FBG and systolic blood pressure (SBP) (respectively, P = 0.01 and 0.02). Median serum 25(OH)D levels were 13.3 ng/mL (CI 95% 12; 15) in MetS and 16 ng/mL (CI 95% 14; 18) (P = 0.01) in non-MetS patients. Among patients with MetS, lower 25(OH)D concentrations were related to higher risk of hypertension (HT) (odds ratio (OR) 1.7, CI 95%, 0.7;4) and hyperglycemia (IFG)/type 2 diabetes (OR 5.5, CI 95% 2; 14). CONCLUSION: Vitamin D status and MetS are inversely correlated in visceral obesity, particularly with regard to glucose homeostasis and BP. More extensive studies are required to investigate the potential for causality. Bioscientifica Ltd 2017-10-31 /pmc/articles/PMC5717541/ /pubmed/29089365 http://dx.doi.org/10.1530/EC-17-0304 Text en © 2017 The authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Research
Piantanida, Eliana
Gallo, Daniela
Veronesi, Giovanni
Dozio, Eugenia
Trotti, Eugenia
Lai, Adriana
Ippolito, Silvia
Sabatino, Jessica
Tanda, Maria Laura
Toniolo, Antonio
Ferrario, Marco
Bartalena, Luigi
Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?
title Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?
title_full Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?
title_fullStr Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?
title_full_unstemmed Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?
title_short Cardiometabolic healthy and unhealthy obesity: does vitamin D play a role?
title_sort cardiometabolic healthy and unhealthy obesity: does vitamin d play a role?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717541/
https://www.ncbi.nlm.nih.gov/pubmed/29089365
http://dx.doi.org/10.1530/EC-17-0304
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