Cargando…

Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury

This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective da...

Descripción completa

Detalles Bibliográficos
Autores principales: Timmermann, Clara Amalie Gade, Choi, Anna L., Petersen, Maria Skaalum, Nielsen, Flemming, Budtz-Jørgensen, Esben, Weihe, Pál, Grandjean, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717715/
https://www.ncbi.nlm.nih.gov/pubmed/29195489
http://dx.doi.org/10.1080/22423982.2017.1406234
_version_ 1783284200274657280
author Timmermann, Clara Amalie Gade
Choi, Anna L.
Petersen, Maria Skaalum
Nielsen, Flemming
Budtz-Jørgensen, Esben
Weihe, Pál
Grandjean, Philippe
author_facet Timmermann, Clara Amalie Gade
Choi, Anna L.
Petersen, Maria Skaalum
Nielsen, Flemming
Budtz-Jørgensen, Esben
Weihe, Pál
Grandjean, Philippe
author_sort Timmermann, Clara Amalie Gade
collection PubMed
description This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother–child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p’-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0–16%), 7% (95% CI = 0–14%) and 9% (95% CI = 2–17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention.
format Online
Article
Text
id pubmed-5717715
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-57177152017-12-11 Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury Timmermann, Clara Amalie Gade Choi, Anna L. Petersen, Maria Skaalum Nielsen, Flemming Budtz-Jørgensen, Esben Weihe, Pál Grandjean, Philippe Int J Circumpolar Health Research Article This study was undertaken to assess the potential impact of maternal exposures to polychlorinated biphenyl (PCB), dichlorodiphenyl dichloroethylene (DDE) and methylmercury on the secondary sex ratios (the ratio of male to female live births) over a span of 23 years. The study includes prospective data from three Faroese birth cohorts, with a total of 2,152 healthy mother–child dyads recruited between 1986 and 2009. The Faroe Islands is a subarctic fishing community, where pilot whale meat and blubber are part of the traditional marine diet. Exposures were measured in maternal hair, serum or umbilical cord blood. Confounder adjusted logistic regression models were used to assess the associations between maternal exposures and the secondary sex ratio. A doubling in ΣPCB, p,p’-DDE and mercury concentrations were associated with increased odds by 8% (95% CI = 0–16%), 7% (95% CI = 0–14%) and 9% (95% CI = 2–17%), respectively, of giving birth to a boy. In conclusion, maternal exposure to ΣPCB, DDE and methylmercury was associated with a slightly increased secondary sex ratio. The impact of paternal exposures could not be taken into account and deserves attention. Taylor & Francis 2017-12-01 /pmc/articles/PMC5717715/ /pubmed/29195489 http://dx.doi.org/10.1080/22423982.2017.1406234 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Timmermann, Clara Amalie Gade
Choi, Anna L.
Petersen, Maria Skaalum
Nielsen, Flemming
Budtz-Jørgensen, Esben
Weihe, Pál
Grandjean, Philippe
Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury
title Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury
title_full Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury
title_fullStr Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury
title_full_unstemmed Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury
title_short Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury
title_sort secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717715/
https://www.ncbi.nlm.nih.gov/pubmed/29195489
http://dx.doi.org/10.1080/22423982.2017.1406234
work_keys_str_mv AT timmermannclaraamaliegade secondarysexratioinrelationtoexposurestopolychlorinatedbiphenylsdichlorodiphenyldichloroethyleneandmethylmercury
AT choiannal secondarysexratioinrelationtoexposurestopolychlorinatedbiphenylsdichlorodiphenyldichloroethyleneandmethylmercury
AT petersenmariaskaalum secondarysexratioinrelationtoexposurestopolychlorinatedbiphenylsdichlorodiphenyldichloroethyleneandmethylmercury
AT nielsenflemming secondarysexratioinrelationtoexposurestopolychlorinatedbiphenylsdichlorodiphenyldichloroethyleneandmethylmercury
AT budtzjørgensenesben secondarysexratioinrelationtoexposurestopolychlorinatedbiphenylsdichlorodiphenyldichloroethyleneandmethylmercury
AT weihepal secondarysexratioinrelationtoexposurestopolychlorinatedbiphenylsdichlorodiphenyldichloroethyleneandmethylmercury
AT grandjeanphilippe secondarysexratioinrelationtoexposurestopolychlorinatedbiphenylsdichlorodiphenyldichloroethyleneandmethylmercury