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Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children

BACKGROUND: Vasovagal syncope (VVS) is the most common cause of syncope in children. Neuropeptide Y (NPY) plays an important role in the regulation of blood pressure (BP), as well as myocardial contractility. This study aimed to explore the role of plasma NPY in VVS in children. METHODS: Fifty-six c...

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Autores principales: Liao, Ying, Xu, Wen-Rui, Li, Hong-Xia, Tang, Chao-Shu, Jin, Hong-Fang, Du, Jun-Bao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717855/
https://www.ncbi.nlm.nih.gov/pubmed/29176136
http://dx.doi.org/10.4103/0366-6999.219157
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author Liao, Ying
Xu, Wen-Rui
Li, Hong-Xia
Tang, Chao-Shu
Jin, Hong-Fang
Du, Jun-Bao
author_facet Liao, Ying
Xu, Wen-Rui
Li, Hong-Xia
Tang, Chao-Shu
Jin, Hong-Fang
Du, Jun-Bao
author_sort Liao, Ying
collection PubMed
description BACKGROUND: Vasovagal syncope (VVS) is the most common cause of syncope in children. Neuropeptide Y (NPY) plays an important role in the regulation of blood pressure (BP), as well as myocardial contractility. This study aimed to explore the role of plasma NPY in VVS in children. METHODS: Fifty-six children who were diagnosed with VVS (VVS group) using head-up tilt test (HUT) and 31 healthy children who were selected as controls (control group) were enrolled. Plasma NPY concentrations were detected. The independent t-test was used to compare the data of the VVS group with those of the control group. The changes in plasma NPY levels in the VVS group during the HUT, as well as hemodynamic parameters, such as heart rate (HR), BP, total peripheral vascular resistance (TPVR), and cardiac output (CO), were evaluated using the paired t-test. Furthermore, the correlations between plasma NPY levels and hemodynamic parameters were analyzed using bivariate correlation analysis. RESULTS: The BP, HR, and plasma NPY (0.34 ± 0.12 pg/ml vs. 0.46 ± 0.13 pg/ml) levels in the supine position were statistically low in the VVS group compared to levels in the control group (all P < 0.05). Plasma NPY levels were positively correlated with the HR (Pearson, R = 0.395, P < 0.001) and diastolic BP (Pearson, R = 0.311, P = 0.003) when patients were in the supine position. When patients in the VVS group were in the supine position, elevated TPVR (4.6 ± 3.7 mmHg·min(−1)·L(−1) vs. 2.5 ± 1.0 mmHg·min(−1)·L(−1), respectively, P < 0.001; 1 mmHg = 0.133 kPa) and reduced CO (1.0 ± 0.7 L/min vs. 2.4 ± 1.3 L/min, respectively, P < 0.001) were observed in the positive-response period compared with baseline values. The plasma NPY levels were positively correlated with TPVR (Spearman, R = 0.294, P = 0.028) but negatively correlated with CO in the positive-response period during HUT (Spearman, R = −0.318, P = 0.017). CONCLUSIONS: Plasma NPY may contribute to the pathogenesis of VVS by increasing the TPVR and decreasing the CO during orthostatic regulation.
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spelling pubmed-57178552017-12-20 Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children Liao, Ying Xu, Wen-Rui Li, Hong-Xia Tang, Chao-Shu Jin, Hong-Fang Du, Jun-Bao Chin Med J (Engl) Original Article BACKGROUND: Vasovagal syncope (VVS) is the most common cause of syncope in children. Neuropeptide Y (NPY) plays an important role in the regulation of blood pressure (BP), as well as myocardial contractility. This study aimed to explore the role of plasma NPY in VVS in children. METHODS: Fifty-six children who were diagnosed with VVS (VVS group) using head-up tilt test (HUT) and 31 healthy children who were selected as controls (control group) were enrolled. Plasma NPY concentrations were detected. The independent t-test was used to compare the data of the VVS group with those of the control group. The changes in plasma NPY levels in the VVS group during the HUT, as well as hemodynamic parameters, such as heart rate (HR), BP, total peripheral vascular resistance (TPVR), and cardiac output (CO), were evaluated using the paired t-test. Furthermore, the correlations between plasma NPY levels and hemodynamic parameters were analyzed using bivariate correlation analysis. RESULTS: The BP, HR, and plasma NPY (0.34 ± 0.12 pg/ml vs. 0.46 ± 0.13 pg/ml) levels in the supine position were statistically low in the VVS group compared to levels in the control group (all P < 0.05). Plasma NPY levels were positively correlated with the HR (Pearson, R = 0.395, P < 0.001) and diastolic BP (Pearson, R = 0.311, P = 0.003) when patients were in the supine position. When patients in the VVS group were in the supine position, elevated TPVR (4.6 ± 3.7 mmHg·min(−1)·L(−1) vs. 2.5 ± 1.0 mmHg·min(−1)·L(−1), respectively, P < 0.001; 1 mmHg = 0.133 kPa) and reduced CO (1.0 ± 0.7 L/min vs. 2.4 ± 1.3 L/min, respectively, P < 0.001) were observed in the positive-response period compared with baseline values. The plasma NPY levels were positively correlated with TPVR (Spearman, R = 0.294, P = 0.028) but negatively correlated with CO in the positive-response period during HUT (Spearman, R = −0.318, P = 0.017). CONCLUSIONS: Plasma NPY may contribute to the pathogenesis of VVS by increasing the TPVR and decreasing the CO during orthostatic regulation. Medknow Publications & Media Pvt Ltd 2017-12-05 /pmc/articles/PMC5717855/ /pubmed/29176136 http://dx.doi.org/10.4103/0366-6999.219157 Text en Copyright: © 2017 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Liao, Ying
Xu, Wen-Rui
Li, Hong-Xia
Tang, Chao-Shu
Jin, Hong-Fang
Du, Jun-Bao
Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children
title Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children
title_full Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children
title_fullStr Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children
title_full_unstemmed Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children
title_short Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children
title_sort plasma neuropeptide y levels in vasovagal syncope in children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717855/
https://www.ncbi.nlm.nih.gov/pubmed/29176136
http://dx.doi.org/10.4103/0366-6999.219157
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