Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer

BACKGROUND: Targeting the type 1 insulin-like growth factor receptor (IGF1R) in breast cancer remains an ongoing clinical challenge. Oncogenic IGF1R-signaling occurs via activation of PI3K/AKT/MAPK downstream mediators which regulate cell proliferation and protein synthesis. To further understand IG...

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Detalles Bibliográficos
Autores principales: Ochnik, Aleksandra M., Baxter, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718000/
https://www.ncbi.nlm.nih.gov/pubmed/29207959
http://dx.doi.org/10.1186/s12885-017-3809-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718000/
https://www.ncbi.nlm.nih.gov/pubmed/29207959
http://dx.doi.org/10.1186/s12885-017-3809-0

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