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Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer

BACKGROUND: Targeting the type 1 insulin-like growth factor receptor (IGF1R) in breast cancer remains an ongoing clinical challenge. Oncogenic IGF1R-signaling occurs via activation of PI3K/AKT/MAPK downstream mediators which regulate cell proliferation and protein synthesis. To further understand IG...

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Detalles Bibliográficos
Autores principales:	Ochnik, Aleksandra M., Baxter, Robert C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718000/ https://www.ncbi.nlm.nih.gov/pubmed/29207959 http://dx.doi.org/10.1186/s12885-017-3809-0

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