Cargando…

Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer

BACKGROUND: Targeting the type 1 insulin-like growth factor receptor (IGF1R) in breast cancer remains an ongoing clinical challenge. Oncogenic IGF1R-signaling occurs via activation of PI3K/AKT/MAPK downstream mediators which regulate cell proliferation and protein synthesis. To further understand IG...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ochnik, Aleksandra M., Baxter, Robert C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718000/ https://www.ncbi.nlm.nih.gov/pubmed/29207959 http://dx.doi.org/10.1186/s12885-017-3809-0

Ejemplares similares

Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation
por: Bernacchioni, Caterina, et al.
Publicado: (2012)

Sphingosine kinase 1 as an anticancer therapeutic target
por: Gao, Ying, et al.
Publicado: (2015)

Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer
por: Kim, Hyun-Soo, et al.
Publicado: (2015)

Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer
por: Zhang, Xihong, et al.
Publicado: (2000)

Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer
por: Hamilton, Nalo, et al.
Publicado: (2017)

Targeting Insulin-Like Growth Factor Binding Protein-3 Signaling in Triple-Negative Breast Cancer
por: Marzec, Kamila A., et al.
Publicado: (2015)

Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma
por: Li, Wenhua, et al.
Publicado: (2016)

The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential Therapeutic Target
por: Wang, Xianwang, et al.
Publicado: (2020)

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer
por: Xu, Guangmeng, et al.
Publicado: (2021)

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer
por: Ohotski, J, et al.
Publicado: (2012)

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor negative breast cancer
por: Ohotski, J, et al.
Publicado: (2012)

Potential of a sphingosine 1-phosphate receptor antagonist and sphingosine kinase inhibitors as targets for multiple myeloma treatment
por: Tanaka, Yuko, et al.
Publicado: (2022)

Characterizing Sphingosine Kinases and Sphingosine 1-Phosphate Receptors in the Mammalian Eye and Retina
por: Porter, Hunter, et al.
Publicado: (2018)

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System
por: Cannavo, Alessandro, et al.
Publicado: (2017)

Identifying novel sphingosine kinase 1 inhibitors as therapeutics against breast cancer
por: Khan, Faez Iqbal, et al.
Publicado: (2019)

The Insulin-like Growth Factor Signaling Pathway in Breast Cancer: An Elusive Therapeutic Target
por: Lee, Ji-Sun, et al.
Publicado: (2022)

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers
por: Pyne, Susan, et al.
Publicado: (2012)

Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade
por: Martin, Janet L., et al.
Publicado: (2017)

Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting
por: Alshaker, Heba, et al.
Publicado: (2019)

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia
por: Dobierzewska, Aneta, et al.
Publicado: (2016)

Signaling Pathways of the Insulin-like Growth Factor Binding Proteins
por: Baxter, Robert C
Publicado: (2023)

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival
por: Olivera, Ana, et al.
Publicado: (1999)

Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2
por: Aji, Gulibositan, et al.
Publicado: (2020)

Preclinical evaluation of Insulin-like growth factor receptor 1 (IGF1R) and Insulin Receptor (IR) as a therapeutic targets in triple negative breast cancer
por: Roche, Sandra, et al.
Publicado: (2023)

Regulatory role of sphingosine kinase and sphingosine-1-phosphate receptor signaling in progenitor/stem cells
por: Ng, Mei Li, et al.
Publicado: (2018)

Drugging Sphingosine Kinases
por: Santos, Webster L., et al.
Publicado: (2014)

Insulin Protects Apoptotic Cardiomyocytes from Hypoxia/Reoxygenation Injury through the Sphingosine Kinase/Sphingosine 1-Phosphate Axis
por: Yu, Huan, et al.
Publicado: (2013)

Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy
por: Gupta, Preeti, et al.
Publicado: (2021)

High Expression of Sphingosine Kinase 1 in Estrogen and Progesterone Receptors-Negative Breast Cancer
por: Nazouri, Azadeh-Sadat, et al.
Publicado: (2017)

Cardiovascular Effects of Pharmacological Targeting of Sphingosine Kinase 1
por: Józefczuk, Ewelina, et al.
Publicado: (2020)

The prognostic values of insulin-like growth factor binding protein in breast cancer
por: Wang, Jiao, et al.
Publicado: (2019)

Prognostic Impact of Sphingosine Kinase 1 in Nonsmall Cell Lung Cancer
por: Motono, Nozomu, et al.
Publicado: (2021)

Sphingosine kinase 1 expression enhances colon tumor growth
por: Furuya, Hideki, et al.
Publicado: (2017)

Role of Insulin-like Growth Factor, Insulin-like Growth Factor Receptors, and Insulin-like Growth Factor-binding Proteins in Ovarian Cancer
por: Amutha, Periyasamy, et al.
Publicado: (2017)

Combined effects on leukemia cell growth by targeting sphingosine kinase 1 and sirtuin 1 signaling
por: Li, Yuxiang, et al.
Publicado: (2020)

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1
por: Sukocheva, Olga, et al.
Publicado: (2006)

Role of sphingosine kinase and sphingosine-1-phosphate receptor in the liver pathology of mice infected with Plasmodium berghei ANKA
por: Techarang, Tachpon, et al.
Publicado: (2022)

Targeting the insulin-like growth factor-1 receptor in human cancer
por: Arcaro, Alexandre
Publicado: (2013)

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer
por: Bao, Yonghua, et al.
Publicado: (2017)

Type 1 insulin-like growth factor receptor targeted therapies in pediatric cancer
por: Wagner, Michael J., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_c7fbs7a7mnl5mrmrlnfag9bqfd