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The feasibility study of using multiple partial volumetric‐modulated arcs therapy in early stage left‐sided breast cancer patients

The purpose of this study was to assess the feasibility of using a multiple partial volumetric‐modulated arcs therapy (MP‐VMAT) technique on the left breast irradiation and to evaluate the dosimetry and treatment efficiency. Ten patients with left‐sided breast cancer who had been treated by whole br...

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Autores principales: Tsai, Ping‐Fang, Lin, Shih‐Min, Lee, Shen‐Hao, Yeh, Chie‐Yi, Huang, Yi‐Ting, Lee, Chung‐Chi, Hong, Ji‐Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718231/
https://www.ncbi.nlm.nih.gov/pubmed/22955645
http://dx.doi.org/10.1120/jacmp.v13i5.3806
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author Tsai, Ping‐Fang
Lin, Shih‐Min
Lee, Shen‐Hao
Yeh, Chie‐Yi
Huang, Yi‐Ting
Lee, Chung‐Chi
Hong, Ji‐Hong
author_facet Tsai, Ping‐Fang
Lin, Shih‐Min
Lee, Shen‐Hao
Yeh, Chie‐Yi
Huang, Yi‐Ting
Lee, Chung‐Chi
Hong, Ji‐Hong
author_sort Tsai, Ping‐Fang
collection PubMed
description The purpose of this study was to assess the feasibility of using a multiple partial volumetric‐modulated arcs therapy (MP‐VMAT) technique on the left breast irradiation and to evaluate the dosimetry and treatment efficiency. Ten patients with left‐sided breast cancer who had been treated by whole breast irradiation were selected for the treatment plan evaluation by using six partial volumetric modulated arcs. Each arc consisted of a 50° gantry rotation. The planning target volumes and the normal organs, including the right breast, the bilateral lungs, left ventricle, heart, and unspecified tissue, were contoured on the CT images. Dose‐volume histograms were generated and the delivery time for each arc was recorded. The PTV received greater than 95% of the [Formula: see text] for all cases, and the maximum dose was within [Formula: see text] of 110% of the prescription dose. The mean homogeneity index (HI) was [Formula: see text] , and mean conformity index (CI) was [Formula: see text]. The mean dose, [Formula: see text] , [Formula: see text] , [Formula: see text] , and [Formula: see text] of the heart were [Formula: see text] , 59.73% [Formula: see text] , 24.39% [Formula: see text] , 2.52% [Formula: see text] , and 1.57% [Formula: see text] , respectively. The volume of the left ventricle receiving 25 Gy was 5.15% [Formula: see text]. The total lung mean dose was [Formula: see text] , with [Formula: see text] of 25.39% [Formula: see text] and [Formula: see text] of 5.66% [Formula: see text]. The right breast received a mean dose of [Formula: see text] , with [Formula: see text] of 1.83% [Formula: see text] and [Formula: see text] of 0.04% [Formula: see text]. The mean dose of unspecified tissue was [Formula: see text] and [Formula: see text] was 22.23% [Formula: see text]. The volume of the unspecified tissue receiving 50 Gy was 0.50% [Formula: see text]. The mean delivery time for each arc was 13.9 seconds. The average MU among ten patients was 511 MU (range 443 to 594 MUs). The MP‐VMAT technique for the left‐sided breast cancer patients achieved adequate target dose coverage while maintaining low doses to organs‐at‐risk, and therefore reduced the potential for induction of second malignancy and side effects. The highly efficient treatment delivery would be beneficial for improving patient throughput, providing patient comfort, and achieving precise treatment with the breathing control system. PACS number: 87.55.‐x, 87.55.D‐, 87.55.dk
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spelling pubmed-57182312018-04-02 The feasibility study of using multiple partial volumetric‐modulated arcs therapy in early stage left‐sided breast cancer patients Tsai, Ping‐Fang Lin, Shih‐Min Lee, Shen‐Hao Yeh, Chie‐Yi Huang, Yi‐Ting Lee, Chung‐Chi Hong, Ji‐Hong J Appl Clin Med Phys Radiation Oncology Physics The purpose of this study was to assess the feasibility of using a multiple partial volumetric‐modulated arcs therapy (MP‐VMAT) technique on the left breast irradiation and to evaluate the dosimetry and treatment efficiency. Ten patients with left‐sided breast cancer who had been treated by whole breast irradiation were selected for the treatment plan evaluation by using six partial volumetric modulated arcs. Each arc consisted of a 50° gantry rotation. The planning target volumes and the normal organs, including the right breast, the bilateral lungs, left ventricle, heart, and unspecified tissue, were contoured on the CT images. Dose‐volume histograms were generated and the delivery time for each arc was recorded. The PTV received greater than 95% of the [Formula: see text] for all cases, and the maximum dose was within [Formula: see text] of 110% of the prescription dose. The mean homogeneity index (HI) was [Formula: see text] , and mean conformity index (CI) was [Formula: see text]. The mean dose, [Formula: see text] , [Formula: see text] , [Formula: see text] , and [Formula: see text] of the heart were [Formula: see text] , 59.73% [Formula: see text] , 24.39% [Formula: see text] , 2.52% [Formula: see text] , and 1.57% [Formula: see text] , respectively. The volume of the left ventricle receiving 25 Gy was 5.15% [Formula: see text]. The total lung mean dose was [Formula: see text] , with [Formula: see text] of 25.39% [Formula: see text] and [Formula: see text] of 5.66% [Formula: see text]. The right breast received a mean dose of [Formula: see text] , with [Formula: see text] of 1.83% [Formula: see text] and [Formula: see text] of 0.04% [Formula: see text]. The mean dose of unspecified tissue was [Formula: see text] and [Formula: see text] was 22.23% [Formula: see text]. The volume of the unspecified tissue receiving 50 Gy was 0.50% [Formula: see text]. The mean delivery time for each arc was 13.9 seconds. The average MU among ten patients was 511 MU (range 443 to 594 MUs). The MP‐VMAT technique for the left‐sided breast cancer patients achieved adequate target dose coverage while maintaining low doses to organs‐at‐risk, and therefore reduced the potential for induction of second malignancy and side effects. The highly efficient treatment delivery would be beneficial for improving patient throughput, providing patient comfort, and achieving precise treatment with the breathing control system. PACS number: 87.55.‐x, 87.55.D‐, 87.55.dk John Wiley and Sons Inc. 2012-09-06 /pmc/articles/PMC5718231/ /pubmed/22955645 http://dx.doi.org/10.1120/jacmp.v13i5.3806 Text en © 2012 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Tsai, Ping‐Fang
Lin, Shih‐Min
Lee, Shen‐Hao
Yeh, Chie‐Yi
Huang, Yi‐Ting
Lee, Chung‐Chi
Hong, Ji‐Hong
The feasibility study of using multiple partial volumetric‐modulated arcs therapy in early stage left‐sided breast cancer patients
title The feasibility study of using multiple partial volumetric‐modulated arcs therapy in early stage left‐sided breast cancer patients
title_full The feasibility study of using multiple partial volumetric‐modulated arcs therapy in early stage left‐sided breast cancer patients
title_fullStr The feasibility study of using multiple partial volumetric‐modulated arcs therapy in early stage left‐sided breast cancer patients
title_full_unstemmed The feasibility study of using multiple partial volumetric‐modulated arcs therapy in early stage left‐sided breast cancer patients
title_short The feasibility study of using multiple partial volumetric‐modulated arcs therapy in early stage left‐sided breast cancer patients
title_sort feasibility study of using multiple partial volumetric‐modulated arcs therapy in early stage left‐sided breast cancer patients
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718231/
https://www.ncbi.nlm.nih.gov/pubmed/22955645
http://dx.doi.org/10.1120/jacmp.v13i5.3806
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