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Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm

The 2016 update of the WHO Classification of Tumours of the Central Nervous System has redefined a number of tumors. Embryonal tumor with multilayered rosettes, C19MC-altered is one such tumor entity which has been newly defined on the basis of a characteristic molecular alteration. We report, to ou...

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Autores principales: Tariq, Muhammad Usman, Ahmad, Zubair, Minhas, Muhammad Khurram, Memon, Aisha, Mushtaq, Noreen, Hawkins, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718304/
https://www.ncbi.nlm.nih.gov/pubmed/29230288
http://dx.doi.org/10.1177/2050313X17745208
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author Tariq, Muhammad Usman
Ahmad, Zubair
Minhas, Muhammad Khurram
Memon, Aisha
Mushtaq, Noreen
Hawkins, Cynthia
author_facet Tariq, Muhammad Usman
Ahmad, Zubair
Minhas, Muhammad Khurram
Memon, Aisha
Mushtaq, Noreen
Hawkins, Cynthia
author_sort Tariq, Muhammad Usman
collection PubMed
description The 2016 update of the WHO Classification of Tumours of the Central Nervous System has redefined a number of tumors. Embryonal tumor with multilayered rosettes, C19MC-altered is one such tumor entity which has been newly defined on the basis of a characteristic molecular alteration. We report, to our knowledge, the first case of this rare pediatric brain neoplasm in the Pakistani population. An 8-month-old girl was presented with vomiting and left-sided ptosis, and magnetic resonance imaging scan showed a cerebellar tumor. Histologically, a highly cellular population of primitive cells was seen alternating with hypocellular neuropil-rich regions containing multilayered true rosettes and cells with glial and neuronal differentiation. Amplification of 19q13. 42 chromosome region on fluorescence in situ hybridization analysis confirmed the diagnosis. Post-operative radiological examination revealed widespread central nervous system involvement. Adjuvant treatment was not offered due to complications. Patient expired a week after diagnosis.
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spelling pubmed-57183042017-12-11 Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm Tariq, Muhammad Usman Ahmad, Zubair Minhas, Muhammad Khurram Memon, Aisha Mushtaq, Noreen Hawkins, Cynthia SAGE Open Med Case Rep Case Report The 2016 update of the WHO Classification of Tumours of the Central Nervous System has redefined a number of tumors. Embryonal tumor with multilayered rosettes, C19MC-altered is one such tumor entity which has been newly defined on the basis of a characteristic molecular alteration. We report, to our knowledge, the first case of this rare pediatric brain neoplasm in the Pakistani population. An 8-month-old girl was presented with vomiting and left-sided ptosis, and magnetic resonance imaging scan showed a cerebellar tumor. Histologically, a highly cellular population of primitive cells was seen alternating with hypocellular neuropil-rich regions containing multilayered true rosettes and cells with glial and neuronal differentiation. Amplification of 19q13. 42 chromosome region on fluorescence in situ hybridization analysis confirmed the diagnosis. Post-operative radiological examination revealed widespread central nervous system involvement. Adjuvant treatment was not offered due to complications. Patient expired a week after diagnosis. SAGE Publications 2017-12-04 /pmc/articles/PMC5718304/ /pubmed/29230288 http://dx.doi.org/10.1177/2050313X17745208 Text en © The Author(s) 2017 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Tariq, Muhammad Usman
Ahmad, Zubair
Minhas, Muhammad Khurram
Memon, Aisha
Mushtaq, Noreen
Hawkins, Cynthia
Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm
title Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm
title_full Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm
title_fullStr Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm
title_full_unstemmed Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm
title_short Embryonal tumor with multilayered rosettes, C19MC-altered: Report of an extremely rare malignant pediatric central nervous system neoplasm
title_sort embryonal tumor with multilayered rosettes, c19mc-altered: report of an extremely rare malignant pediatric central nervous system neoplasm
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718304/
https://www.ncbi.nlm.nih.gov/pubmed/29230288
http://dx.doi.org/10.1177/2050313X17745208
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