The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment

We investigated the expression of the Alzheimer’s disease-related metabolic brain pattern (ADRP) in (18)F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer’s disease (AD) after five or more years of clinical follow-up, 95 MCI patients who...

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Autores principales: Meles, Sanne K, Pagani, Marco, Arnaldi, Dario, De Carli, Fabrizio, Dessi, Barbara, Morbelli, Silvia, Sambuceti, Gianmario, Jonsson, Cathrine, Leenders, Klaus L, Nobili, Flavio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718332/
https://www.ncbi.nlm.nih.gov/pubmed/28929833
http://dx.doi.org/10.1177/0271678X17732508
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author Meles, Sanne K
Pagani, Marco
Arnaldi, Dario
De Carli, Fabrizio
Dessi, Barbara
Morbelli, Silvia
Sambuceti, Gianmario
Jonsson, Cathrine
Leenders, Klaus L
Nobili, Flavio
author_facet Meles, Sanne K
Pagani, Marco
Arnaldi, Dario
De Carli, Fabrizio
Dessi, Barbara
Morbelli, Silvia
Sambuceti, Gianmario
Jonsson, Cathrine
Leenders, Klaus L
Nobili, Flavio
author_sort Meles, Sanne K
collection PubMed
description We investigated the expression of the Alzheimer’s disease-related metabolic brain pattern (ADRP) in (18)F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer’s disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of (18)F-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression.
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spelling pubmed-57183322018-12-01 The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment Meles, Sanne K Pagani, Marco Arnaldi, Dario De Carli, Fabrizio Dessi, Barbara Morbelli, Silvia Sambuceti, Gianmario Jonsson, Cathrine Leenders, Klaus L Nobili, Flavio J Cereb Blood Flow Metab Brief Report We investigated the expression of the Alzheimer’s disease-related metabolic brain pattern (ADRP) in (18)F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer’s disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%). Assessment of (18)F-FDG-PET scans on a case-by-case basis using the ADRP may be useful for quantifying disease progression. SAGE Publications 2017-09-20 2017-12 /pmc/articles/PMC5718332/ /pubmed/28929833 http://dx.doi.org/10.1177/0271678X17732508 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Brief Report
Meles, Sanne K
Pagani, Marco
Arnaldi, Dario
De Carli, Fabrizio
Dessi, Barbara
Morbelli, Silvia
Sambuceti, Gianmario
Jonsson, Cathrine
Leenders, Klaus L
Nobili, Flavio
The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment
title The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment
title_full The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment
title_fullStr The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment
title_full_unstemmed The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment
title_short The Alzheimer’s disease metabolic brain pattern in mild cognitive impairment
title_sort alzheimer’s disease metabolic brain pattern in mild cognitive impairment
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718332/
https://www.ncbi.nlm.nih.gov/pubmed/28929833
http://dx.doi.org/10.1177/0271678X17732508
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