The Role of Iron Metabolism in Lung Inflammation and Injury

Iron is required for many vital functions including oxygen transport and energy metabolism. Protective mechanisms maintain optimal iron concentration involving dynamic regulation of the transporters and iron storage proteins. In addition to these systemic regulatory mechanisms, the unique lung envir...

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Detalles Bibliográficos
Autores principales: Kim, Jonghan, Wessling-Resnick, Marianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718378/
https://www.ncbi.nlm.nih.gov/pubmed/29226014
http://dx.doi.org/10.4172/2155-6121.S4-004
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author Kim, Jonghan
Wessling-Resnick, Marianne
author_facet Kim, Jonghan
Wessling-Resnick, Marianne
author_sort Kim, Jonghan
collection PubMed
description Iron is required for many vital functions including oxygen transport and energy metabolism. Protective mechanisms maintain optimal iron concentration involving dynamic regulation of the transporters and iron storage proteins. In addition to these systemic regulatory mechanisms, the unique lung environment must provide detoxification from metal-induced oxidative stress and pathogenic infections. This review focuses on the unique role of iron metabolism in lung injury and inflammation.
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spelling pubmed-57183782017-12-06 The Role of Iron Metabolism in Lung Inflammation and Injury Kim, Jonghan Wessling-Resnick, Marianne J Allergy Ther Article Iron is required for many vital functions including oxygen transport and energy metabolism. Protective mechanisms maintain optimal iron concentration involving dynamic regulation of the transporters and iron storage proteins. In addition to these systemic regulatory mechanisms, the unique lung environment must provide detoxification from metal-induced oxidative stress and pathogenic infections. This review focuses on the unique role of iron metabolism in lung injury and inflammation. 2012-01-25 2012 /pmc/articles/PMC5718378/ /pubmed/29226014 http://dx.doi.org/10.4172/2155-6121.S4-004 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Kim, Jonghan
Wessling-Resnick, Marianne
The Role of Iron Metabolism in Lung Inflammation and Injury
title The Role of Iron Metabolism in Lung Inflammation and Injury
title_full The Role of Iron Metabolism in Lung Inflammation and Injury
title_fullStr The Role of Iron Metabolism in Lung Inflammation and Injury
title_full_unstemmed The Role of Iron Metabolism in Lung Inflammation and Injury
title_short The Role of Iron Metabolism in Lung Inflammation and Injury
title_sort role of iron metabolism in lung inflammation and injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718378/
https://www.ncbi.nlm.nih.gov/pubmed/29226014
http://dx.doi.org/10.4172/2155-6121.S4-004
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