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Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016

Enteroviruses (EVs) cause severe outbreaks of respiratory and neurological disease as illustrated by EV-D68 and EV-A71 outbreaks, respectively. We have mapped European laboratory capacity for identification and characterisation of non-polio EVs to improve preparedness to respond to (re)-emerging EVs...

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Autores principales: Harvala, Heli, Jasir, Aftab, Penttinen, Pasi, Pastore Celentano, Lucia, Greco, Donato, Broberg, Eeva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718392/
https://www.ncbi.nlm.nih.gov/pubmed/29162204
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.45.16-00807
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author Harvala, Heli
Jasir, Aftab
Penttinen, Pasi
Pastore Celentano, Lucia
Greco, Donato
Broberg, Eeva
author_facet Harvala, Heli
Jasir, Aftab
Penttinen, Pasi
Pastore Celentano, Lucia
Greco, Donato
Broberg, Eeva
author_sort Harvala, Heli
collection PubMed
description Enteroviruses (EVs) cause severe outbreaks of respiratory and neurological disease as illustrated by EV-D68 and EV-A71 outbreaks, respectively. We have mapped European laboratory capacity for identification and characterisation of non-polio EVs to improve preparedness to respond to (re)-emerging EVs linked to severe disease. An online questionnaire on non-polio EV surveillance and laboratory detection was submitted to all 30 European Union (EU)/European Economic Area (EEA) countries. Twenty-nine countries responded; 26 conducted laboratory-based non-polio EV surveillance, and 24 included neurological infections in their surveillance. Eleven countries have established specific surveillance for EV-D68 via sentinel influenza surveillance (n = 7), typing EV-positive respiratory samples (n = 10) and/or acute flaccid paralysis surveillance (n = 5). Of 26 countries performing non-polio EV characterisation/typing, 10 further characterised culture-positive EV isolates, whereas the remainder typed PCR-positive but culture-negative samples. Although 19 countries have introduced sequence-based EV typing, seven still rely entirely on virus isolation. Based on 2015 data, six countries typed over 300 specimens mostly by sequencing, whereas 11 countries characterised under 50 EV-positive samples. EV surveillance activity varied between EU/EEA countries, and did not always specifically target patients with neurological and/or respiratory infections. Introduction of sequence-based typing methods is needed throughout the EU/EEA to enhance laboratory capacity for the detection of EVs.
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spelling pubmed-57183922017-12-20 Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016 Harvala, Heli Jasir, Aftab Penttinen, Pasi Pastore Celentano, Lucia Greco, Donato Broberg, Eeva Euro Surveill Surveillance and Outbreak Report Enteroviruses (EVs) cause severe outbreaks of respiratory and neurological disease as illustrated by EV-D68 and EV-A71 outbreaks, respectively. We have mapped European laboratory capacity for identification and characterisation of non-polio EVs to improve preparedness to respond to (re)-emerging EVs linked to severe disease. An online questionnaire on non-polio EV surveillance and laboratory detection was submitted to all 30 European Union (EU)/European Economic Area (EEA) countries. Twenty-nine countries responded; 26 conducted laboratory-based non-polio EV surveillance, and 24 included neurological infections in their surveillance. Eleven countries have established specific surveillance for EV-D68 via sentinel influenza surveillance (n = 7), typing EV-positive respiratory samples (n = 10) and/or acute flaccid paralysis surveillance (n = 5). Of 26 countries performing non-polio EV characterisation/typing, 10 further characterised culture-positive EV isolates, whereas the remainder typed PCR-positive but culture-negative samples. Although 19 countries have introduced sequence-based EV typing, seven still rely entirely on virus isolation. Based on 2015 data, six countries typed over 300 specimens mostly by sequencing, whereas 11 countries characterised under 50 EV-positive samples. EV surveillance activity varied between EU/EEA countries, and did not always specifically target patients with neurological and/or respiratory infections. Introduction of sequence-based typing methods is needed throughout the EU/EEA to enhance laboratory capacity for the detection of EVs. European Centre for Disease Prevention and Control (ECDC) 2017-11-09 /pmc/articles/PMC5718392/ /pubmed/29162204 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.45.16-00807 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Harvala, Heli
Jasir, Aftab
Penttinen, Pasi
Pastore Celentano, Lucia
Greco, Donato
Broberg, Eeva
Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016
title Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016
title_full Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016
title_fullStr Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016
title_full_unstemmed Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016
title_short Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016
title_sort surveillance and laboratory detection for non-polio enteroviruses in the european union/european economic area, 2016
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718392/
https://www.ncbi.nlm.nih.gov/pubmed/29162204
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.45.16-00807
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