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Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016
Enteroviruses (EVs) cause severe outbreaks of respiratory and neurological disease as illustrated by EV-D68 and EV-A71 outbreaks, respectively. We have mapped European laboratory capacity for identification and characterisation of non-polio EVs to improve preparedness to respond to (re)-emerging EVs...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718392/ https://www.ncbi.nlm.nih.gov/pubmed/29162204 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.45.16-00807 |
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author | Harvala, Heli Jasir, Aftab Penttinen, Pasi Pastore Celentano, Lucia Greco, Donato Broberg, Eeva |
author_facet | Harvala, Heli Jasir, Aftab Penttinen, Pasi Pastore Celentano, Lucia Greco, Donato Broberg, Eeva |
author_sort | Harvala, Heli |
collection | PubMed |
description | Enteroviruses (EVs) cause severe outbreaks of respiratory and neurological disease as illustrated by EV-D68 and EV-A71 outbreaks, respectively. We have mapped European laboratory capacity for identification and characterisation of non-polio EVs to improve preparedness to respond to (re)-emerging EVs linked to severe disease. An online questionnaire on non-polio EV surveillance and laboratory detection was submitted to all 30 European Union (EU)/European Economic Area (EEA) countries. Twenty-nine countries responded; 26 conducted laboratory-based non-polio EV surveillance, and 24 included neurological infections in their surveillance. Eleven countries have established specific surveillance for EV-D68 via sentinel influenza surveillance (n = 7), typing EV-positive respiratory samples (n = 10) and/or acute flaccid paralysis surveillance (n = 5). Of 26 countries performing non-polio EV characterisation/typing, 10 further characterised culture-positive EV isolates, whereas the remainder typed PCR-positive but culture-negative samples. Although 19 countries have introduced sequence-based EV typing, seven still rely entirely on virus isolation. Based on 2015 data, six countries typed over 300 specimens mostly by sequencing, whereas 11 countries characterised under 50 EV-positive samples. EV surveillance activity varied between EU/EEA countries, and did not always specifically target patients with neurological and/or respiratory infections. Introduction of sequence-based typing methods is needed throughout the EU/EEA to enhance laboratory capacity for the detection of EVs. |
format | Online Article Text |
id | pubmed-5718392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-57183922017-12-20 Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016 Harvala, Heli Jasir, Aftab Penttinen, Pasi Pastore Celentano, Lucia Greco, Donato Broberg, Eeva Euro Surveill Surveillance and Outbreak Report Enteroviruses (EVs) cause severe outbreaks of respiratory and neurological disease as illustrated by EV-D68 and EV-A71 outbreaks, respectively. We have mapped European laboratory capacity for identification and characterisation of non-polio EVs to improve preparedness to respond to (re)-emerging EVs linked to severe disease. An online questionnaire on non-polio EV surveillance and laboratory detection was submitted to all 30 European Union (EU)/European Economic Area (EEA) countries. Twenty-nine countries responded; 26 conducted laboratory-based non-polio EV surveillance, and 24 included neurological infections in their surveillance. Eleven countries have established specific surveillance for EV-D68 via sentinel influenza surveillance (n = 7), typing EV-positive respiratory samples (n = 10) and/or acute flaccid paralysis surveillance (n = 5). Of 26 countries performing non-polio EV characterisation/typing, 10 further characterised culture-positive EV isolates, whereas the remainder typed PCR-positive but culture-negative samples. Although 19 countries have introduced sequence-based EV typing, seven still rely entirely on virus isolation. Based on 2015 data, six countries typed over 300 specimens mostly by sequencing, whereas 11 countries characterised under 50 EV-positive samples. EV surveillance activity varied between EU/EEA countries, and did not always specifically target patients with neurological and/or respiratory infections. Introduction of sequence-based typing methods is needed throughout the EU/EEA to enhance laboratory capacity for the detection of EVs. European Centre for Disease Prevention and Control (ECDC) 2017-11-09 /pmc/articles/PMC5718392/ /pubmed/29162204 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.45.16-00807 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Surveillance and Outbreak Report Harvala, Heli Jasir, Aftab Penttinen, Pasi Pastore Celentano, Lucia Greco, Donato Broberg, Eeva Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016 |
title | Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016 |
title_full | Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016 |
title_fullStr | Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016 |
title_full_unstemmed | Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016 |
title_short | Surveillance and laboratory detection for non-polio enteroviruses in the European Union/European Economic Area, 2016 |
title_sort | surveillance and laboratory detection for non-polio enteroviruses in the european union/european economic area, 2016 |
topic | Surveillance and Outbreak Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718392/ https://www.ncbi.nlm.nih.gov/pubmed/29162204 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.45.16-00807 |
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