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The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants

OBJECTIVE: There has been a significant increase in the prescribing of medication for chronic non-cancer pain. In a UK population sample, we aimed to assess cardio-metabolic (CM) health in those taking these chronic pain medications. METHODS: 133,401 participants from the UK Biobank cohort were stud...

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Autores principales: Cassidy, Sophie, Trenell, Michael I., Anderson, Kirstie N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718411/
https://www.ncbi.nlm.nih.gov/pubmed/29211804
http://dx.doi.org/10.1371/journal.pone.0187982
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author Cassidy, Sophie
Trenell, Michael I.
Anderson, Kirstie N.
author_facet Cassidy, Sophie
Trenell, Michael I.
Anderson, Kirstie N.
author_sort Cassidy, Sophie
collection PubMed
description OBJECTIVE: There has been a significant increase in the prescribing of medication for chronic non-cancer pain. In a UK population sample, we aimed to assess cardio-metabolic (CM) health in those taking these chronic pain medications. METHODS: 133,401 participants from the UK Biobank cohort were studied. BMI, waist cm and hypertension were compared between those on drugs prescribed for chronic pain and CM drugs to those on CM drugs only. Multiple confounders were controlled for. RESULTS: Those taking opiates and CM drugs had the worst CM health profile with a 95%, 82% and 63% increased odds of reporting obesity, ‘very high risk’ waist circumference and hypertension, respectively (OR [95% CI] 1.95 [1.75–2.17], 1.82 [1.63–2.03], 1.63 [1.45–1.84]), compared to those on CM drugs alone. Those taking neuropathic pain medications and CM drugs also demonstrate worse CM profile than those taking CM drugs only. CONCLUSIONS: The impact of medications for chronic pain and sleep upon CM health and obesity is of concern for these classes of drugs which have been recently labelled as dependency forming medications. The results from this cross sectional study warrants further investigation and adds further support to calls for these medications to be prescribed for shorter periods.
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spelling pubmed-57184112017-12-15 The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants Cassidy, Sophie Trenell, Michael I. Anderson, Kirstie N. PLoS One Research Article OBJECTIVE: There has been a significant increase in the prescribing of medication for chronic non-cancer pain. In a UK population sample, we aimed to assess cardio-metabolic (CM) health in those taking these chronic pain medications. METHODS: 133,401 participants from the UK Biobank cohort were studied. BMI, waist cm and hypertension were compared between those on drugs prescribed for chronic pain and CM drugs to those on CM drugs only. Multiple confounders were controlled for. RESULTS: Those taking opiates and CM drugs had the worst CM health profile with a 95%, 82% and 63% increased odds of reporting obesity, ‘very high risk’ waist circumference and hypertension, respectively (OR [95% CI] 1.95 [1.75–2.17], 1.82 [1.63–2.03], 1.63 [1.45–1.84]), compared to those on CM drugs alone. Those taking neuropathic pain medications and CM drugs also demonstrate worse CM profile than those taking CM drugs only. CONCLUSIONS: The impact of medications for chronic pain and sleep upon CM health and obesity is of concern for these classes of drugs which have been recently labelled as dependency forming medications. The results from this cross sectional study warrants further investigation and adds further support to calls for these medications to be prescribed for shorter periods. Public Library of Science 2017-12-06 /pmc/articles/PMC5718411/ /pubmed/29211804 http://dx.doi.org/10.1371/journal.pone.0187982 Text en © 2017 Cassidy et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cassidy, Sophie
Trenell, Michael I.
Anderson, Kirstie N.
The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants
title The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants
title_full The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants
title_fullStr The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants
title_full_unstemmed The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants
title_short The cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 UK Biobank participants
title_sort cardio-metabolic impact of taking commonly prescribed analgesic drugs in 133,401 uk biobank participants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718411/
https://www.ncbi.nlm.nih.gov/pubmed/29211804
http://dx.doi.org/10.1371/journal.pone.0187982
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