Forward planned intensity modulated radiotherapy (IMRT) for whole breast postoperative radiotherapy. Is it useful? When?

The purpose was to compare the dosimetric results observed in 201 breast cancer patients submitted to tangential forward intensity‐modulated radiation therapy (IMRT) with those observed in 131 patients treated with a standard wedged 3D technique for postoperative treatment of whole breast, according to breast size and supraclavicular node irradiation. Following dosimetric parameters were used for the comparison: [Formula: see text] and [Formula: see text] for the irradiated volume; [Formula: see text] and [Formula: see text] for the ipsilateral lung; [Formula: see text] and [Formula: see text] for the heart. Stratification was made according to breast size and supraclavicular (SCV) nodal irradiation. As respect to irradiated volume, a significant reduction of [Formula: see text] (mean values: [Formula: see text] versus [Formula: see text]) and [Formula: see text] (mean % values: [Formula: see text] versus [Formula: see text]), and an increase of [Formula: see text] (mean % values: [Formula: see text] versus [Formula: see text]) were observed with forward IMRT. The homogeneity of dose distribution to target volume significantly improved with forward IMRT in all patient groups, irrespective of breast size or supraclavicular nodal irradiation. When patients treated with supraclavicular nodal irradiation were excluded from the analysis, forward IMRT slightly reduced [Formula: see text] (mean values: [Formula: see text] versus [Formula: see text]) and [Formula: see text] (mean values [Formula: see text] versus [Formula: see text]) of the ipsilateral lung. The dose to the heart tended to be lower with IMRT but this difference was not statistically significant. Tangential forward IMRT in postoperative treatment of whole breast improved dosimetric parameters in terms of homogeneity of dose distribution to the target in a large sample of patients, independent of breast size or supraclavicular nodal irradiation. Lung irradiation was slightly reduced in patients not undergoing to supraclavicular irradiation. PACS numbers: 87.53.Kn; 87.55.de