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Plant-made vaccines and reagents for the One Health initiative
The One Health initiative is increasingly becoming a prominent discussion topic in animal and human health, with its focus on prevention of spread of zoonotic diseases, both in animals, and from animals to humans. An important part of One Health is that diagnostics and vaccines for diseases may be t...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718809/ https://www.ncbi.nlm.nih.gov/pubmed/28846485 http://dx.doi.org/10.1080/21645515.2017.1356497 |
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author | Rybicki, Edward Peter |
author_facet | Rybicki, Edward Peter |
author_sort | Rybicki, Edward Peter |
collection | PubMed |
description | The One Health initiative is increasingly becoming a prominent discussion topic in animal and human health, with its focus on prevention of spread of zoonotic diseases, both in animals, and from animals to humans. An important part of One Health is that diagnostics and vaccines for diseases may be the same thing – and be used for both humans and animals. One potential problem standing in the way of wider adoption of One Health principles, though, is that use of conventional cell fermentation systems for production of the recombinant proteins that could be used as diagnostics or vaccines is often expensive and is not easily scalable. A solution to this may be the use of plants or plant cells as bioreactors: molecular farming, or the production of biologics in plants, is now a well-established science with many proofs of principle and important proofs of efficacy for especially animal vaccines. This review discusses how molecular farming could enable important advances in One Health, using as examples plant-made vacccines, reagents and therapeutics for influenza viruses, ebolaviruses, rabies virus, bunyaviruses and flaviviruses. |
format | Online Article Text |
id | pubmed-5718809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-57188092017-12-11 Plant-made vaccines and reagents for the One Health initiative Rybicki, Edward Peter Hum Vaccin Immunother Review The One Health initiative is increasingly becoming a prominent discussion topic in animal and human health, with its focus on prevention of spread of zoonotic diseases, both in animals, and from animals to humans. An important part of One Health is that diagnostics and vaccines for diseases may be the same thing – and be used for both humans and animals. One potential problem standing in the way of wider adoption of One Health principles, though, is that use of conventional cell fermentation systems for production of the recombinant proteins that could be used as diagnostics or vaccines is often expensive and is not easily scalable. A solution to this may be the use of plants or plant cells as bioreactors: molecular farming, or the production of biologics in plants, is now a well-established science with many proofs of principle and important proofs of efficacy for especially animal vaccines. This review discusses how molecular farming could enable important advances in One Health, using as examples plant-made vacccines, reagents and therapeutics for influenza viruses, ebolaviruses, rabies virus, bunyaviruses and flaviviruses. Taylor & Francis 2017-08-28 /pmc/articles/PMC5718809/ /pubmed/28846485 http://dx.doi.org/10.1080/21645515.2017.1356497 Text en © 2017 Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Review Rybicki, Edward Peter Plant-made vaccines and reagents for the One Health initiative |
title | Plant-made vaccines and reagents for the One Health initiative |
title_full | Plant-made vaccines and reagents for the One Health initiative |
title_fullStr | Plant-made vaccines and reagents for the One Health initiative |
title_full_unstemmed | Plant-made vaccines and reagents for the One Health initiative |
title_short | Plant-made vaccines and reagents for the One Health initiative |
title_sort | plant-made vaccines and reagents for the one health initiative |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718809/ https://www.ncbi.nlm.nih.gov/pubmed/28846485 http://dx.doi.org/10.1080/21645515.2017.1356497 |
work_keys_str_mv | AT rybickiedwardpeter plantmadevaccinesandreagentsfortheonehealthinitiative |