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Chimpanzee adenoviral vectors as vaccines for outbreak pathogens

The 2014–15 Ebola outbreak in West Africa highlighted the potential for large disease outbreaks caused by emerging pathogens and has generated considerable focus on preparedness for future epidemics. Here we discuss drivers, strategies and practical considerations for developing vaccines against out...

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Autores principales: Ewer, Katie, Sebastian, Sarah, Spencer, Alexandra J., Gilbert, Sarah, Hill, Adrian V. S., Lambe, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718829/
https://www.ncbi.nlm.nih.gov/pubmed/29083948
http://dx.doi.org/10.1080/21645515.2017.1383575
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author Ewer, Katie
Sebastian, Sarah
Spencer, Alexandra J.
Gilbert, Sarah
Hill, Adrian V. S.
Lambe, Teresa
author_facet Ewer, Katie
Sebastian, Sarah
Spencer, Alexandra J.
Gilbert, Sarah
Hill, Adrian V. S.
Lambe, Teresa
author_sort Ewer, Katie
collection PubMed
description The 2014–15 Ebola outbreak in West Africa highlighted the potential for large disease outbreaks caused by emerging pathogens and has generated considerable focus on preparedness for future epidemics. Here we discuss drivers, strategies and practical considerations for developing vaccines against outbreak pathogens. Chimpanzee adenoviral (ChAd) vectors have been developed as vaccine candidates for multiple infectious diseases and prostate cancer. ChAd vectors are safe and induce antigen-specific cellular and humoral immunity in all age groups, as well as circumventing the problem of pre-existing immunity encountered with human Ad vectors. For these reasons, such viral vectors provide an attractive platform for stockpiling vaccines for emergency deployment in response to a threatened outbreak of an emerging pathogen. Work is already underway to develop vaccines against a number of other outbreak pathogens and we will also review progress on these approaches here, particularly for Lassa fever, Nipah and MERS.
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spelling pubmed-57188292017-12-11 Chimpanzee adenoviral vectors as vaccines for outbreak pathogens Ewer, Katie Sebastian, Sarah Spencer, Alexandra J. Gilbert, Sarah Hill, Adrian V. S. Lambe, Teresa Hum Vaccin Immunother Research Papers The 2014–15 Ebola outbreak in West Africa highlighted the potential for large disease outbreaks caused by emerging pathogens and has generated considerable focus on preparedness for future epidemics. Here we discuss drivers, strategies and practical considerations for developing vaccines against outbreak pathogens. Chimpanzee adenoviral (ChAd) vectors have been developed as vaccine candidates for multiple infectious diseases and prostate cancer. ChAd vectors are safe and induce antigen-specific cellular and humoral immunity in all age groups, as well as circumventing the problem of pre-existing immunity encountered with human Ad vectors. For these reasons, such viral vectors provide an attractive platform for stockpiling vaccines for emergency deployment in response to a threatened outbreak of an emerging pathogen. Work is already underway to develop vaccines against a number of other outbreak pathogens and we will also review progress on these approaches here, particularly for Lassa fever, Nipah and MERS. Taylor & Francis 2017-10-30 /pmc/articles/PMC5718829/ /pubmed/29083948 http://dx.doi.org/10.1080/21645515.2017.1383575 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Papers
Ewer, Katie
Sebastian, Sarah
Spencer, Alexandra J.
Gilbert, Sarah
Hill, Adrian V. S.
Lambe, Teresa
Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
title Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
title_full Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
title_fullStr Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
title_full_unstemmed Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
title_short Chimpanzee adenoviral vectors as vaccines for outbreak pathogens
title_sort chimpanzee adenoviral vectors as vaccines for outbreak pathogens
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718829/
https://www.ncbi.nlm.nih.gov/pubmed/29083948
http://dx.doi.org/10.1080/21645515.2017.1383575
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