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CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression
Inflammation is a host defense process against infection. Inflammatory mediators include cytokines of the interleukin-1 family, such as IL-1α and IL-1β. Unlike IL-1β, IL-1α carries an N-terminal nuclear localisation sequence (NLS) and is trafficked to the nucleus. The importance of IL-1α nuclear loc...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719027/ https://www.ncbi.nlm.nih.gov/pubmed/29213066 http://dx.doi.org/10.1038/s41598-017-17387-x |