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Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin

Animal health depends on the ability of immune cells to kill invading pathogens, and on the resilience of tissues to tolerate the presence of pathogens. Trueperella pyogenes causes tissue pathology in many mammals by secreting a cholesterol-dependent cytolysin, pyolysin (PLO), which targets stromal...

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Detalles Bibliográficos
Autores principales:	Griffin, Sholeem, Preta, Giulio, Sheldon, Iain Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719056/ https://www.ncbi.nlm.nih.gov/pubmed/29213055 http://dx.doi.org/10.1038/s41598-017-17138-y

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