Vitamin K2 Prevents Lymphoma in Drosophila

Previous studies have established the anticancer effect of vitamin K2 (VK2). However, its effect on lymphoma induced by UBIAD1/heix mutation in Drosophila remains unknown. Therefore, we aimed to develop an in vivo model of lymphoma for the precise characterization of lymphoma phenotypes. We also aim...

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Autores principales: Dragh, Maytham A., Xu, Zhiliang, Al-Allak, Zainab S., Hong, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719063/
https://www.ncbi.nlm.nih.gov/pubmed/29213118
http://dx.doi.org/10.1038/s41598-017-17270-9
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author Dragh, Maytham A.
Xu, Zhiliang
Al-Allak, Zainab S.
Hong, Ling
author_facet Dragh, Maytham A.
Xu, Zhiliang
Al-Allak, Zainab S.
Hong, Ling
author_sort Dragh, Maytham A.
collection PubMed
description Previous studies have established the anticancer effect of vitamin K2 (VK2). However, its effect on lymphoma induced by UBIAD1/heix mutation in Drosophila remains unknown. Therefore, we aimed to develop an in vivo model of lymphoma for the precise characterization of lymphoma phenotypes. We also aimed to improve the understanding of the mechanisms that underlie the preventative effects of VK2 on lymphoma. Our results demonstrated that VK2 prevents lymphoma by acting as an electron carrier and by correcting the function and structure of mitochondria by inhibiting mitochondrial reactive oxygen species production mtROS. Our work identifies mitochondria as a key player in cancer therapy strategies.
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spelling pubmed-57190632017-12-08 Vitamin K2 Prevents Lymphoma in Drosophila Dragh, Maytham A. Xu, Zhiliang Al-Allak, Zainab S. Hong, Ling Sci Rep Article Previous studies have established the anticancer effect of vitamin K2 (VK2). However, its effect on lymphoma induced by UBIAD1/heix mutation in Drosophila remains unknown. Therefore, we aimed to develop an in vivo model of lymphoma for the precise characterization of lymphoma phenotypes. We also aimed to improve the understanding of the mechanisms that underlie the preventative effects of VK2 on lymphoma. Our results demonstrated that VK2 prevents lymphoma by acting as an electron carrier and by correcting the function and structure of mitochondria by inhibiting mitochondrial reactive oxygen species production mtROS. Our work identifies mitochondria as a key player in cancer therapy strategies. Nature Publishing Group UK 2017-12-06 /pmc/articles/PMC5719063/ /pubmed/29213118 http://dx.doi.org/10.1038/s41598-017-17270-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Dragh, Maytham A.
Xu, Zhiliang
Al-Allak, Zainab S.
Hong, Ling
Vitamin K2 Prevents Lymphoma in Drosophila
title Vitamin K2 Prevents Lymphoma in Drosophila
title_full Vitamin K2 Prevents Lymphoma in Drosophila
title_fullStr Vitamin K2 Prevents Lymphoma in Drosophila
title_full_unstemmed Vitamin K2 Prevents Lymphoma in Drosophila
title_short Vitamin K2 Prevents Lymphoma in Drosophila
title_sort vitamin k2 prevents lymphoma in drosophila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719063/
https://www.ncbi.nlm.nih.gov/pubmed/29213118
http://dx.doi.org/10.1038/s41598-017-17270-9
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AT xuzhiliang vitamink2preventslymphomaindrosophila
AT alallakzainabs vitamink2preventslymphomaindrosophila
AT hongling vitamink2preventslymphomaindrosophila

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