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NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma

Chromatin modifying enzymes are frequently mutated in cancer, resulting in widespread epigenetic deregulation. Recent reports indicate that inactivating mutations in the histone methyltransferase NSD1 define an intrinsic subtype of head and neck squamous cell carcinoma (HNSC) that features pronounce...

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Detalles Bibliográficos
Autores principales:	Brennan, Kevin, Shin, June Ho, Tay, Joshua K., Prunello, Marcos, Gentles, Andrew J., Sunwoo, John B., Gevaert, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719078/ https://www.ncbi.nlm.nih.gov/pubmed/29213088 http://dx.doi.org/10.1038/s41598-017-17298-x

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