Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors

Metalloproteinase inhibitors often feature hydroxamate moieties to facilitate the chelation of metal ions in the catalytic center of target enzymes. Actinonin and matlystatins are  potent metalloproteinase inhibitors that comprise rare N-hydroxy-2-pentyl-succinamic acid warheads. Here we report the...

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Detalles Bibliográficos
Autores principales: Leipoldt, Franziska, Santos-Aberturas, Javier, Stegmann, Dennis P., Wolf, Felix, Kulik, Andreas, Lacret, Rodney, Popadić, Désirée, Keinhörster, Daniela, Kirchner, Norbert, Bekiesch, Paulina, Gross, Harald, Truman, Andrew W., Kaysser, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719088/
https://www.ncbi.nlm.nih.gov/pubmed/29213087
http://dx.doi.org/10.1038/s41467-017-01975-6

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