Cargando…

Design and synthesis of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole derivatives as colchicine binding site inhibitors

A series of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazol derivatives were designed as potential microtubule targeting agents. The regioselective alkylation of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole was predicted by computations and confirmed by an unambiguous synthetic r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Yue, Feng, Dongjie, Gao, Meiqi, Wang, Zhiwei, Yan, Peng, Gu, Zhenzhen, Guan, Qi, Zuo, Daiying, Bao, Kai, Sun, Jun, Wu, Yingliang, Zhang, Weige
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719359/ https://www.ncbi.nlm.nih.gov/pubmed/29215079 http://dx.doi.org/10.1038/s41598-017-17449-0

Ejemplares similares

Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers
por: Wang, Chao, et al.
Publicado: (2021)

Synthesis and Properties of 6-Aryl-4-azidocinnolines and 6-Aryl-4-(1,2,3-1H-triazol-1-yl)cinnolines
por: Danilkina, Natalia A., et al.
Publicado: (2019)

A Comparative Study of Molybdenum Carbonyl and Oxomolybdenum Derivatives Bearing 1,2,3-Triazole or 1,2,4-Triazole in Catalytic Olefin Epoxidation
por: Nogueira, Lucie S., et al.
Publicado: (2018)

Features of the behavior of 4-amino-5-carboxamido-1,2,3-triazole in multicomponent heterocyclizations with carbonyl compounds
por: Gladkov, Eugene S, et al.
Publicado: (2012)

4-Desoxy-4β-(4-methoxycarbonyl-1,2,3-triazol-1-yl)podophyllotoxin dichloromethane solvate
por: Zuo, Song, et al.
Publicado: (2009)

Palladium-Catalyzed C–H Arylation of 1,2,3-Triazoles
por: Zhang, Chengwei, et al.
Publicado: (2016)

Synthesis and Biological Evaluation of 3-Alkyl-1,5-Diaryl-1H-Pyrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative Activity
por: Xu, Qile, et al.
Publicado: (2015)

Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors
por: Xu, Qile, et al.
Publicado: (2017)

1,2,3-Triazoles
por: Rachwal, S., et al.
Publicado: (2008)

Design and Synthesis of New 5-aryl-4-Arylethynyl-1H-1,2,3-triazoles with Valuable Photophysical and Biological Properties
por: Efremova, Mariia M., et al.
Publicado: (2021)

Methyl 1-benzyl-1H-1,2,3-triazole-4-carboxylate
por: Huang, Chiung-Cheng, et al.
Publicado: (2010)

Methyl 1H-1,2,3-triazole-4-carboxylate
por: Prabakaran, K., et al.
Publicado: (2009)

Synthesis of (1,2,3-triazol-4-yl)methyl Phosphinates and (1,2,3-Triazol-4-yl)methyl Phosphates by Copper-Catalyzed Azide-Alkyne Cycloaddition
por: Tripolszky, Anna, et al.
Publicado: (2019)

Novel Double-Modified Colchicine Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, and Biological Activity Evaluation
por: Krzywik, Julia, et al.
Publicado: (2021)

Synthesis methods of 1,2,3-/1,2,4-triazoles: A review
por: Dai, Jinlian, et al.
Publicado: (2022)

Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
por: Beyki, Khalil, et al.
Publicado: (2016)

Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity
por: Sun, Maolin, et al.
Publicado: (2017)

Design, Synthesis, and Antifungal Activity of Novel Aryl-1,2,3-Triazole-β-Carboline Hybrids
por: Huo, Xin-Yu, et al.
Publicado: (2018)

3-Benzylsulfanyl-5-(4-phenyl-1H-1,2,3-triazol-1-ylmethyl)-4H-1,2,4-triazol-4-amine
por: Chu, Qing-Zhu, et al.
Publicado: (2008)

1-Benzyl-4-(naphthalen-1-yl)-1H-1,2,3-triazole
por: Sarmiento-Sánchez, Juan I., et al.
Publicado: (2011)

An Efﬁcient Synthesis of 1-Aryl-3-(indole-3-yl)-3-(2-aryl-1,2,3-triazol-4-yl)propan-1-one Catalyzed by a Brønsted Acid Ionic Liquid
por: Liu, Chen-Jiang, et al.
Publicado: (2010)

Methyl 1-methyl-1H-1,2,3-triazole-4-carboxylate
por: Khan, F. Nawaz, et al.
Publicado: (2010)

Synthesis of Bis(1,2,3-Triazole) Functionalized Quinoline-2,4-Diones †
por: Milićević, David, et al.
Publicado: (2018)

Copper-catalyzed in situ oxidative-coupling for one-pot synthesis of 5-aryl-1,4-disubstituted 1,2,3-triazoles under mild conditions
por: Wang, Chao, et al.
Publicado: (2021)

Preparation of Acidic 5-Hydroxy-1,2,3-triazoles via the Cycloaddition of Aryl Azides with β-Ketoesters
por: Pacifico, Roberta, et al.
Publicado: (2021)

Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y(14) Receptor Antagonists
por: Junker, Anna, et al.
Publicado: (2016)

Revisiting ring-degenerate rearrangements of 1-substituted-4-imino-1,2,3-triazoles
por: Fletcher, James T, et al.
Publicado: (2018)

A recent overview on the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles
por: Shiri, Pezhman, et al.
Publicado: (2021)

Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl-1,2,4-Triazoles
por: Colanceska-Ragenovic, Katica, et al.
Publicado: (2001)

1,2,3-Triazole based bisphosphine, 5-(diphenylphosphanyl)-1-(2-(diphenylphosphanyl)-phenyl)-4-phenyl-1H-1,2,3-triazole: an ambidentate ligand with switchable coordination modes
por: Radhakrishna, Latchupatula, et al.
Publicado: (2018)

New 1,2,3-Triazole/1,2,4-triazole Hybrids as Aromatase Inhibitors: Design, Synthesis, and Apoptotic Antiproliferative Activity
por: Maghraby, Mohamed T-E, et al.
Publicado: (2023)

Synthesis and Antimicrobial Activity of 4-Substituted 1,2,3-Triazole-Coumarin Derivatives
por: López-Rojas, Priscila, et al.
Publicado: (2018)

Sensitive Energetics from the N‐Amination of 4‐Nitro‐1,2,3‐Triazole
por: Wozniak, Dominique R., et al.
Publicado: (2020)

4-(4-Hydroxymethyl-1H-1,2,3-triazol-1-yl)benzoic acid
por: Ishak, Dayang Hazwani Abang, et al.
Publicado: (2011)

Methyl 2-methyl-2H-1,2,3-triazole-4-carboxylate
por: Prabakaran, K., et al.
Publicado: (2009)

2-[1-(1-Naphthyl)-1H-1,2,3-triazol-4-yl]pyridine
por: Happ, Bobby, et al.
Publicado: (2009)

Synthesis and Characterization of Novel 2-(1,2,3-Triazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)thiazoles and 2-(4,5-Dihydro-1H-pyrazol-1-yl)-4-(1H-1,2,3-triazol-4-yl)thiazoles
por: Kariuki, Benson M., et al.
Publicado: (2022)

Thermogravimetric analysis, kinetic study, and pyrolysis–GC/MS analysis of 1,1ʹ-azobis-1,2,3-triazole and 4,4ʹ-azobis-1,2,4-triazole
por: Jia, Chenhui, et al.
Publicado: (2018)

Synthesis and Determination of Physicochemical Properties of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Alkoxyethoxybenzoates
por: Marvanova, Pavlina, et al.
Publicado: (2016)

Synthesis and Characterization of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Propoxybenzoates and Their Hydrochloride Salts
por: Marvanova, Pavlina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4itoppcocnqi0eg6hibgddcloj