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A PLAG1 mutation contributed to stature recovery in modern cattle
The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of ~1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 muta...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719367/ https://www.ncbi.nlm.nih.gov/pubmed/29215042 http://dx.doi.org/10.1038/s41598-017-17127-1 |
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| author | Utsunomiya, Yuri Tani Milanesi, Marco Utsunomiya, Adam Taiti Harth Torrecilha, Rafaela Beatriz Pintor Kim, Eui-Soo Costa, Márcio Silva Aguiar, Tamíris Sayuri Schroeder, Steven do Carmo, Adriana Santana Carvalheiro, Roberto Neves, Haroldo Henrique Rezende Padula, Romulo Cláudio Morozini Sussai, Thayla Souza Zavarez, Ludmilla Balbo Cipriano, Rafael Silva Caminhas, Maria Margareth Theodoro Hambrecht, George Colli, Licia Eufemi, Elisa Ajmone-Marsan, Paolo Cesana, Deneb Sannazaro, Marco Buora, Maurizio Morgante, Michele Liu, George Bickhart, Derek Van Tassell, Curtis Paul Sölkner, Johann Sonstegard, Tad Stewart Garcia, José Fernando |
| author_facet | Utsunomiya, Yuri Tani Milanesi, Marco Utsunomiya, Adam Taiti Harth Torrecilha, Rafaela Beatriz Pintor Kim, Eui-Soo Costa, Márcio Silva Aguiar, Tamíris Sayuri Schroeder, Steven do Carmo, Adriana Santana Carvalheiro, Roberto Neves, Haroldo Henrique Rezende Padula, Romulo Cláudio Morozini Sussai, Thayla Souza Zavarez, Ludmilla Balbo Cipriano, Rafael Silva Caminhas, Maria Margareth Theodoro Hambrecht, George Colli, Licia Eufemi, Elisa Ajmone-Marsan, Paolo Cesana, Deneb Sannazaro, Marco Buora, Maurizio Morgante, Michele Liu, George Bickhart, Derek Van Tassell, Curtis Paul Sölkner, Johann Sonstegard, Tad Stewart Garcia, José Fernando |
| author_sort | Utsunomiya, Yuri Tani |
| collection | PubMed |
| description | The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of ~1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16(th) and 18(th) centuries. Towards the 19(th) and 20(th) centuries, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait. |
| format | Online Article Text |
| id | pubmed-5719367 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-57193672017-12-08 A PLAG1 mutation contributed to stature recovery in modern cattle Utsunomiya, Yuri Tani Milanesi, Marco Utsunomiya, Adam Taiti Harth Torrecilha, Rafaela Beatriz Pintor Kim, Eui-Soo Costa, Márcio Silva Aguiar, Tamíris Sayuri Schroeder, Steven do Carmo, Adriana Santana Carvalheiro, Roberto Neves, Haroldo Henrique Rezende Padula, Romulo Cláudio Morozini Sussai, Thayla Souza Zavarez, Ludmilla Balbo Cipriano, Rafael Silva Caminhas, Maria Margareth Theodoro Hambrecht, George Colli, Licia Eufemi, Elisa Ajmone-Marsan, Paolo Cesana, Deneb Sannazaro, Marco Buora, Maurizio Morgante, Michele Liu, George Bickhart, Derek Van Tassell, Curtis Paul Sölkner, Johann Sonstegard, Tad Stewart Garcia, José Fernando Sci Rep Article The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of ~1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16(th) and 18(th) centuries. Towards the 19(th) and 20(th) centuries, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait. Nature Publishing Group UK 2017-12-07 /pmc/articles/PMC5719367/ /pubmed/29215042 http://dx.doi.org/10.1038/s41598-017-17127-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Utsunomiya, Yuri Tani Milanesi, Marco Utsunomiya, Adam Taiti Harth Torrecilha, Rafaela Beatriz Pintor Kim, Eui-Soo Costa, Márcio Silva Aguiar, Tamíris Sayuri Schroeder, Steven do Carmo, Adriana Santana Carvalheiro, Roberto Neves, Haroldo Henrique Rezende Padula, Romulo Cláudio Morozini Sussai, Thayla Souza Zavarez, Ludmilla Balbo Cipriano, Rafael Silva Caminhas, Maria Margareth Theodoro Hambrecht, George Colli, Licia Eufemi, Elisa Ajmone-Marsan, Paolo Cesana, Deneb Sannazaro, Marco Buora, Maurizio Morgante, Michele Liu, George Bickhart, Derek Van Tassell, Curtis Paul Sölkner, Johann Sonstegard, Tad Stewart Garcia, José Fernando A PLAG1 mutation contributed to stature recovery in modern cattle |
| title | A PLAG1 mutation contributed to stature recovery in modern cattle |
| title_full | A PLAG1 mutation contributed to stature recovery in modern cattle |
| title_fullStr | A PLAG1 mutation contributed to stature recovery in modern cattle |
| title_full_unstemmed | A PLAG1 mutation contributed to stature recovery in modern cattle |
| title_short | A PLAG1 mutation contributed to stature recovery in modern cattle |
| title_sort | plag1 mutation contributed to stature recovery in modern cattle |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719367/ https://www.ncbi.nlm.nih.gov/pubmed/29215042 http://dx.doi.org/10.1038/s41598-017-17127-1 |
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