Sex-related pharmacokinetic differences and mechanisms of metapristone (RU486 metabolite)

Metapristone is the primary metabolite of the abortifacient mifepristone (RU486), and is being developed as a safe and effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically investigated the sex-related pharmacokinetics of metapristone in both rats and dogs, and ex...

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Detalles Bibliográficos
Autores principales: Chen, Wenge, Xiao, Yingying, Chen, Jianzhong, Liu, Jian, Shao, Jingwei, Li, Tao, Zhu, Yewei, Ma, Ji, Gao, Yu, Wang, Jichuang, Xu, Jianguo, Lu, Yusheng, Jia, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719405/
https://www.ncbi.nlm.nih.gov/pubmed/29215040
http://dx.doi.org/10.1038/s41598-017-17225-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719405/
https://www.ncbi.nlm.nih.gov/pubmed/29215040
http://dx.doi.org/10.1038/s41598-017-17225-0

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