Local Production of Activated Factor X in Atherosclerotic Plaque Induced Vascular Smooth Muscle Cell Senescence

Our previous study demonstrated that coagulation factor Xa (FXa) induced endothelial cell senescence, resulting in inflammation and impaired angiogenesis. This mechanism is dictated through protease-activated receptors, PARs, insulin-like growth factor-binding protein 5 (IGFBP-5), and p53. Activatio...

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Detalles Bibliográficos
Autores principales: Sanada, Fumihiro, Muratsu, Jun, Otsu, Rei, Shimizu, Hideo, Koibuchi, Nobutaka, Uchida, Kazutaka, Taniyama, Yoshiaki, Yoshimura, Shinichi, Rakugi, Hiromi, Morishita, Ryuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719421/
https://www.ncbi.nlm.nih.gov/pubmed/29215061
http://dx.doi.org/10.1038/s41598-017-17508-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719421/
https://www.ncbi.nlm.nih.gov/pubmed/29215061
http://dx.doi.org/10.1038/s41598-017-17508-6

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