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The evolution of the macrophage-specific enhancer (Fms intronic regulatory element) within the CSF1R locus of vertebrates

The Csf1r locus encodes the receptor for macrophage colony-stimulating factor, which controls the proliferation, differentiation and survival of macrophages. The 300 bp Fms intronic regulatory element (FIRE), within the second intron of Csf1r, is necessary and sufficient to direct macrophage-specifi...

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Detalles Bibliográficos
Autores principales: Hume, David A., Wollscheid-Lengeling, Evi, Rojo, Rocio, Pridans, Clare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719456/
https://www.ncbi.nlm.nih.gov/pubmed/29215000
http://dx.doi.org/10.1038/s41598-017-15999-x