GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

BACKGROUND: The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor progression. GPER is a transcriptional target of hypoxia inducible factor 1 alp...

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Detalles Bibliográficos
Autores principales: De Francesco, Ernestina M., Sims, Andrew H., Maggiolini, Marcello, Sotgia, Federica, Lisanti, Michael P., Clarke, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719673/
https://www.ncbi.nlm.nih.gov/pubmed/29212519
http://dx.doi.org/10.1186/s13058-017-0923-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719673/
https://www.ncbi.nlm.nih.gov/pubmed/29212519
http://dx.doi.org/10.1186/s13058-017-0923-5

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