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GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

BACKGROUND: The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor progression. GPER is a transcriptional target of hypoxia inducible factor 1 alp...

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Detalles Bibliográficos
Autores principales:	De Francesco, Ernestina M., Sims, Andrew H., Maggiolini, Marcello, Sotgia, Federica, Lisanti, Michael P., Clarke, Robert B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719673/ https://www.ncbi.nlm.nih.gov/pubmed/29212519 http://dx.doi.org/10.1186/s13058-017-0923-5

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