Cargando…

The utility of non‐axial treatment beam orientations for lower lobe lung cancers

Traditional treatment beams for non‐small–cell lung cancer are limited to the axial plane. For many tumor geometries, non‐axial orientations appear to reduce the dose to normal tissues (e.g. heart, liver). We hypothesize that non‐axial beams provide a significant reduction in incidental irradiation...

Descripción completa

Detalles Bibliográficos
Autores principales: Quaranta, Brian P., Das, Shiva K., Shafman, Timothy D., Light, Kim L., Marks, Lawrence B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719787/
https://www.ncbi.nlm.nih.gov/pubmed/20160689
http://dx.doi.org/10.1120/jacmp.v11i1.3010
_version_ 1783284557761478656
author Quaranta, Brian P.
Das, Shiva K.
Shafman, Timothy D.
Light, Kim L.
Marks, Lawrence B.
author_facet Quaranta, Brian P.
Das, Shiva K.
Shafman, Timothy D.
Light, Kim L.
Marks, Lawrence B.
author_sort Quaranta, Brian P.
collection PubMed
description Traditional treatment beams for non‐small–cell lung cancer are limited to the axial plane. For many tumor geometries, non‐axial orientations appear to reduce the dose to normal tissues (e.g. heart, liver). We hypothesize that non‐axial beams provide a significant reduction in incidental irradiation of the heart and liver, while maintaining adequate target coverage. CT scans of twenty‐four patients with lower lobe lung cancers were studied. For each patient, an opposed oblique axial beam pair and a competing non‐axial opposed oblique pair were generated, both off‐cord. The competing plans delivered comparable doses/margins to the GTV. DVHs and integral doses were computed for all structures of interest for the two competing plans. The integral dose was compared for axial and non‐axial beams for each contoured organ using a paired t‐test. Dose to the heart was significantly lower for the non‐axial plans ([Formula: see text]). For 20/24 patients, the integral heart dose was reduced by using non‐axial beams. In those patients with tumors located in the inferior right lower lobe, a lower dose to the liver was achieved when non‐axial beams were used. There were no meaningful differences in dose to the GTV, lungs, or skin between axial and non‐axial beams. Non‐axial beams can reduce the dose to the heart and liver in patients with lower lobe lung cancers. Non‐axial beams may be clinically beneficial in these patients and should be considered as an option during planning. PACS number: 87.55.de
format Online
Article
Text
id pubmed-5719787
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-57197872018-04-02 The utility of non‐axial treatment beam orientations for lower lobe lung cancers Quaranta, Brian P. Das, Shiva K. Shafman, Timothy D. Light, Kim L. Marks, Lawrence B. J Appl Clin Med Phys Radiation Oncology Physics Traditional treatment beams for non‐small–cell lung cancer are limited to the axial plane. For many tumor geometries, non‐axial orientations appear to reduce the dose to normal tissues (e.g. heart, liver). We hypothesize that non‐axial beams provide a significant reduction in incidental irradiation of the heart and liver, while maintaining adequate target coverage. CT scans of twenty‐four patients with lower lobe lung cancers were studied. For each patient, an opposed oblique axial beam pair and a competing non‐axial opposed oblique pair were generated, both off‐cord. The competing plans delivered comparable doses/margins to the GTV. DVHs and integral doses were computed for all structures of interest for the two competing plans. The integral dose was compared for axial and non‐axial beams for each contoured organ using a paired t‐test. Dose to the heart was significantly lower for the non‐axial plans ([Formula: see text]). For 20/24 patients, the integral heart dose was reduced by using non‐axial beams. In those patients with tumors located in the inferior right lower lobe, a lower dose to the liver was achieved when non‐axial beams were used. There were no meaningful differences in dose to the GTV, lungs, or skin between axial and non‐axial beams. Non‐axial beams can reduce the dose to the heart and liver in patients with lower lobe lung cancers. Non‐axial beams may be clinically beneficial in these patients and should be considered as an option during planning. PACS number: 87.55.de John Wiley and Sons Inc. 2010-01-28 /pmc/articles/PMC5719787/ /pubmed/20160689 http://dx.doi.org/10.1120/jacmp.v11i1.3010 Text en © 2010 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Quaranta, Brian P.
Das, Shiva K.
Shafman, Timothy D.
Light, Kim L.
Marks, Lawrence B.
The utility of non‐axial treatment beam orientations for lower lobe lung cancers
title The utility of non‐axial treatment beam orientations for lower lobe lung cancers
title_full The utility of non‐axial treatment beam orientations for lower lobe lung cancers
title_fullStr The utility of non‐axial treatment beam orientations for lower lobe lung cancers
title_full_unstemmed The utility of non‐axial treatment beam orientations for lower lobe lung cancers
title_short The utility of non‐axial treatment beam orientations for lower lobe lung cancers
title_sort utility of non‐axial treatment beam orientations for lower lobe lung cancers
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719787/
https://www.ncbi.nlm.nih.gov/pubmed/20160689
http://dx.doi.org/10.1120/jacmp.v11i1.3010
work_keys_str_mv AT quarantabrianp theutilityofnonaxialtreatmentbeamorientationsforlowerlobelungcancers
AT dasshivak theutilityofnonaxialtreatmentbeamorientationsforlowerlobelungcancers
AT shafmantimothyd theutilityofnonaxialtreatmentbeamorientationsforlowerlobelungcancers
AT lightkiml theutilityofnonaxialtreatmentbeamorientationsforlowerlobelungcancers
AT markslawrenceb theutilityofnonaxialtreatmentbeamorientationsforlowerlobelungcancers
AT quarantabrianp utilityofnonaxialtreatmentbeamorientationsforlowerlobelungcancers
AT dasshivak utilityofnonaxialtreatmentbeamorientationsforlowerlobelungcancers
AT shafmantimothyd utilityofnonaxialtreatmentbeamorientationsforlowerlobelungcancers
AT lightkiml utilityofnonaxialtreatmentbeamorientationsforlowerlobelungcancers
AT markslawrenceb utilityofnonaxialtreatmentbeamorientationsforlowerlobelungcancers