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Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem

Control of the lower urinary tract (LUT) requires complex neuronal circuits that involve elements located at the peripheral nervous system and at different levels of the central nervous system. Spinal cord injury (SCI) interrupts these neuronal circuits and jeopardizes the voluntary control of bladd...

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Detalles Bibliográficos
Autores principales: Cruz, Célia Duarte, Cruz, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720001/
https://www.ncbi.nlm.nih.gov/pubmed/21258763
http://dx.doi.org/10.1100/tsw.2011.26
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author Cruz, Célia Duarte
Cruz, Francisco
author_facet Cruz, Célia Duarte
Cruz, Francisco
author_sort Cruz, Célia Duarte
collection PubMed
description Control of the lower urinary tract (LUT) requires complex neuronal circuits that involve elements located at the peripheral nervous system and at different levels of the central nervous system. Spinal cord injury (SCI) interrupts these neuronal circuits and jeopardizes the voluntary control of bladder function. In most cases, SCI results in a period of bladder areflexia, followed by the emergence of neurogenic detrusor overactivity (NDO). Only recently, researchers have started to have a clearer vision ofthe mechanisms of SCI-induced changes affecting LUT control. For example, changes in the urothelium have recently been described and proposed to play a role in NDO. As such, a better understanding of NDO has generated new opportunities to investigate novel therapeutic approaches for NDO.In the present paper, we aim to update recent data concerning SCI-induced LUT dysfunction and therapeutic approaches commonly used to deal with NDO. We make a brief description of LUT control and changes occurring after SCI, and refer to new therapeutic options, including vanniloids and botulinum toxin. Finally, we discuss mechanisms of spinal cord repair, an interesting and very active area of investigation that has obtained some promising results in the recovery of LUT control.
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spelling pubmed-57200012017-12-21 Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem Cruz, Célia Duarte Cruz, Francisco ScientificWorldJournal Review Article Control of the lower urinary tract (LUT) requires complex neuronal circuits that involve elements located at the peripheral nervous system and at different levels of the central nervous system. Spinal cord injury (SCI) interrupts these neuronal circuits and jeopardizes the voluntary control of bladder function. In most cases, SCI results in a period of bladder areflexia, followed by the emergence of neurogenic detrusor overactivity (NDO). Only recently, researchers have started to have a clearer vision ofthe mechanisms of SCI-induced changes affecting LUT control. For example, changes in the urothelium have recently been described and proposed to play a role in NDO. As such, a better understanding of NDO has generated new opportunities to investigate novel therapeutic approaches for NDO.In the present paper, we aim to update recent data concerning SCI-induced LUT dysfunction and therapeutic approaches commonly used to deal with NDO. We make a brief description of LUT control and changes occurring after SCI, and refer to new therapeutic options, including vanniloids and botulinum toxin. Finally, we discuss mechanisms of spinal cord repair, an interesting and very active area of investigation that has obtained some promising results in the recovery of LUT control. TheScientificWorldJOURNAL 2011-01-18 /pmc/articles/PMC5720001/ /pubmed/21258763 http://dx.doi.org/10.1100/tsw.2011.26 Text en Copyright © 2011 Celia Cruz and Francisco Cruz. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cruz, Célia Duarte
Cruz, Francisco
Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem
title Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem
title_full Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem
title_fullStr Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem
title_full_unstemmed Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem
title_short Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem
title_sort spinal cord injury and bladder dysfunction: new ideas about an old problem
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720001/
https://www.ncbi.nlm.nih.gov/pubmed/21258763
http://dx.doi.org/10.1100/tsw.2011.26
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