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Plasmablastic Lymphoma: A Systematic Review

Plasmablastic lymphoma (PBL) is a very aggressive variant of diffuse large B-cell lymphoma initially described in the oral cavity of HIV-infected individuals. PBL represents a diagnostic challenge given its characteristic morphology and lack of CD20 expression, and also a therapeutic challenge, with...

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Detalles Bibliográficos
Autores principales: Castillo, Jorge J., Reagan, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720057/
https://www.ncbi.nlm.nih.gov/pubmed/21442146
http://dx.doi.org/10.1100/tsw.2011.59
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author Castillo, Jorge J.
Reagan, John L.
author_facet Castillo, Jorge J.
Reagan, John L.
author_sort Castillo, Jorge J.
collection PubMed
description Plasmablastic lymphoma (PBL) is a very aggressive variant of diffuse large B-cell lymphoma initially described in the oral cavity of HIV-infected individuals. PBL represents a diagnostic challenge given its characteristic morphology and lack of CD20 expression, and also a therapeutic challenge, with early responses to therapy, but with high relapse rates and poor prognosis. In recent years, our understanding and clinical experience with PBL has increased in both HIV-positive and -negative settings. However, given its rarity, most of the data available rely on case reports and case series. The main goal of this article is to systematically review the most recent advances in epidemiology; pathophysiology; clinical, pathologic, and molecular characteristics; therapy; and prognosis in patients with PBL. Specific covered topics include new pathological markers for diagnosis, its association with Epstein-Barr virus, and the need of more intensive therapies.
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spelling pubmed-57200572017-12-21 Plasmablastic Lymphoma: A Systematic Review Castillo, Jorge J. Reagan, John L. ScientificWorldJournal Review Article Plasmablastic lymphoma (PBL) is a very aggressive variant of diffuse large B-cell lymphoma initially described in the oral cavity of HIV-infected individuals. PBL represents a diagnostic challenge given its characteristic morphology and lack of CD20 expression, and also a therapeutic challenge, with early responses to therapy, but with high relapse rates and poor prognosis. In recent years, our understanding and clinical experience with PBL has increased in both HIV-positive and -negative settings. However, given its rarity, most of the data available rely on case reports and case series. The main goal of this article is to systematically review the most recent advances in epidemiology; pathophysiology; clinical, pathologic, and molecular characteristics; therapy; and prognosis in patients with PBL. Specific covered topics include new pathological markers for diagnosis, its association with Epstein-Barr virus, and the need of more intensive therapies. TheScientificWorldJOURNAL 2011-03-22 /pmc/articles/PMC5720057/ /pubmed/21442146 http://dx.doi.org/10.1100/tsw.2011.59 Text en Copyright © 2011 Jorge J. Castillo and John L. Reagan. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Castillo, Jorge J.
Reagan, John L.
Plasmablastic Lymphoma: A Systematic Review
title Plasmablastic Lymphoma: A Systematic Review
title_full Plasmablastic Lymphoma: A Systematic Review
title_fullStr Plasmablastic Lymphoma: A Systematic Review
title_full_unstemmed Plasmablastic Lymphoma: A Systematic Review
title_short Plasmablastic Lymphoma: A Systematic Review
title_sort plasmablastic lymphoma: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720057/
https://www.ncbi.nlm.nih.gov/pubmed/21442146
http://dx.doi.org/10.1100/tsw.2011.59
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