7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity

Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhi...

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Detalles Bibliográficos
Autores principales: Duval, Auri R., Carvalho, Pedro H., Soares, Maieli C., Gouvêa, Daniela P., Siqueira, Geonir M., Lund, Rafael G., Cunico, Wilson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720066/
https://www.ncbi.nlm.nih.gov/pubmed/21805018
http://dx.doi.org/10.1100/tsw.2011.141
Descripción
Sumario:Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents.

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