Cargando…
7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity
Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhi...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
TheScientificWorldJOURNAL
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720066/ https://www.ncbi.nlm.nih.gov/pubmed/21805018 http://dx.doi.org/10.1100/tsw.2011.141 |
_version_ | 1783284611980197888 |
---|---|
author | Duval, Auri R. Carvalho, Pedro H. Soares, Maieli C. Gouvêa, Daniela P. Siqueira, Geonir M. Lund, Rafael G. Cunico, Wilson |
author_facet | Duval, Auri R. Carvalho, Pedro H. Soares, Maieli C. Gouvêa, Daniela P. Siqueira, Geonir M. Lund, Rafael G. Cunico, Wilson |
author_sort | Duval, Auri R. |
collection | PubMed |
description | Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents. |
format | Online Article Text |
id | pubmed-5720066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-57200662017-12-21 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity Duval, Auri R. Carvalho, Pedro H. Soares, Maieli C. Gouvêa, Daniela P. Siqueira, Geonir M. Lund, Rafael G. Cunico, Wilson ScientificWorldJournal Short Communication Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents. TheScientificWorldJOURNAL 2011-07-28 /pmc/articles/PMC5720066/ /pubmed/21805018 http://dx.doi.org/10.1100/tsw.2011.141 Text en Copyright © 2011 Auri R. Duval et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Duval, Auri R. Carvalho, Pedro H. Soares, Maieli C. Gouvêa, Daniela P. Siqueira, Geonir M. Lund, Rafael G. Cunico, Wilson 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
title | 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
title_full | 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
title_fullStr | 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
title_full_unstemmed | 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
title_short | 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity |
title_sort | 7-chloroquinolin-4-yl arylhydrazone derivatives: synthesis and antifungal activity |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720066/ https://www.ncbi.nlm.nih.gov/pubmed/21805018 http://dx.doi.org/10.1100/tsw.2011.141 |
work_keys_str_mv | AT duvalaurir 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity AT carvalhopedroh 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity AT soaresmaielic 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity AT gouveadanielap 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity AT siqueirageonirm 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity AT lundrafaelg 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity AT cunicowilson 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity |