Cargando…

7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity

Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhi...

Descripción completa

Detalles Bibliográficos
Autores principales: Duval, Auri R., Carvalho, Pedro H., Soares, Maieli C., Gouvêa, Daniela P., Siqueira, Geonir M., Lund, Rafael G., Cunico, Wilson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720066/
https://www.ncbi.nlm.nih.gov/pubmed/21805018
http://dx.doi.org/10.1100/tsw.2011.141
_version_ 1783284611980197888
author Duval, Auri R.
Carvalho, Pedro H.
Soares, Maieli C.
Gouvêa, Daniela P.
Siqueira, Geonir M.
Lund, Rafael G.
Cunico, Wilson
author_facet Duval, Auri R.
Carvalho, Pedro H.
Soares, Maieli C.
Gouvêa, Daniela P.
Siqueira, Geonir M.
Lund, Rafael G.
Cunico, Wilson
author_sort Duval, Auri R.
collection PubMed
description Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents.
format Online
Article
Text
id pubmed-5720066
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher TheScientificWorldJOURNAL
record_format MEDLINE/PubMed
spelling pubmed-57200662017-12-21 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity Duval, Auri R. Carvalho, Pedro H. Soares, Maieli C. Gouvêa, Daniela P. Siqueira, Geonir M. Lund, Rafael G. Cunico, Wilson ScientificWorldJournal Short Communication Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with the first-line drug fluconazole. These results could be considered as an important starting point for the rational design of new antifungal agents. TheScientificWorldJOURNAL 2011-07-28 /pmc/articles/PMC5720066/ /pubmed/21805018 http://dx.doi.org/10.1100/tsw.2011.141 Text en Copyright © 2011 Auri R. Duval et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Duval, Auri R.
Carvalho, Pedro H.
Soares, Maieli C.
Gouvêa, Daniela P.
Siqueira, Geonir M.
Lund, Rafael G.
Cunico, Wilson
7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity
title 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity
title_full 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity
title_fullStr 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity
title_full_unstemmed 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity
title_short 7-Chloroquinolin-4-yl Arylhydrazone Derivatives: Synthesis and Antifungal Activity
title_sort 7-chloroquinolin-4-yl arylhydrazone derivatives: synthesis and antifungal activity
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720066/
https://www.ncbi.nlm.nih.gov/pubmed/21805018
http://dx.doi.org/10.1100/tsw.2011.141
work_keys_str_mv AT duvalaurir 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity
AT carvalhopedroh 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity
AT soaresmaielic 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity
AT gouveadanielap 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity
AT siqueirageonirm 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity
AT lundrafaelg 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity
AT cunicowilson 7chloroquinolin4ylarylhydrazonederivativessynthesisandantifungalactivity