Cargando…

Frontiers in Vitamin Research: New Antibodies, New Data

Since 2004, the anatomical distribution of vitamins in the monkey brain, studied using immunohistochemical techniques and new tools (specific antisera that discriminate different vitamins reasonably well), has been an ongoing research field. The visualization of immunoreactive structures containing...

Descripción completa

Detalles Bibliográficos
Autores principales: Coveñas, Rafael, Mangas, Arturo, Bodet, Dominique, Duleu, Sébastien, Marcos, Pilar, Karakas, Begum, Geffard, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720100/
https://www.ncbi.nlm.nih.gov/pubmed/21666992
http://dx.doi.org/10.1100/tsw.2011.115
_version_ 1783284620850102272
author Coveñas, Rafael
Mangas, Arturo
Bodet, Dominique
Duleu, Sébastien
Marcos, Pilar
Karakas, Begum
Geffard, Michel
author_facet Coveñas, Rafael
Mangas, Arturo
Bodet, Dominique
Duleu, Sébastien
Marcos, Pilar
Karakas, Begum
Geffard, Michel
author_sort Coveñas, Rafael
collection PubMed
description Since 2004, the anatomical distribution of vitamins in the monkey brain, studied using immunohistochemical techniques and new tools (specific antisera that discriminate different vitamins reasonably well), has been an ongoing research field. The visualization of immunoreactive structures containing vitamins (folic acid, riboflavin, thiamine, pyridoxal, and vitamin C) has recently been reported in the monkey brain (Macaca fascicularis), all these vitamins showing a restricted or very restricted distribution. Folic acid, thiamine, and riboflavin have only been observed in immunoreactive fibers, vitamin C has only been found in cell bodies (located in the primary somatosensory cortex), and pyridoxal has been found in both fibers and cell bodies. Perikarya containing pyridoxal have been observed in the paraventricular hypothalamic nucleus, the periventricular hypothalamic region, and in the supraoptic nucleus. The fibers containing vitamins are thick, smooth (without varicosities), and are of medium length or long, whereas immunoreactive cell bodies containing vitamins are round or triangular. At present, there are insufficient data to elucidate the roles played by vitamins in the brain, but the anatomical distribution of these compounds in the monkey brain provides a general idea (although imprecise and requiring much more study) about the possible functional implications of these molecules. In this sense, here the possible functional roles played by vitamins are discussed.
format Online
Article
Text
id pubmed-5720100
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher TheScientificWorldJOURNAL
record_format MEDLINE/PubMed
spelling pubmed-57201002017-12-21 Frontiers in Vitamin Research: New Antibodies, New Data Coveñas, Rafael Mangas, Arturo Bodet, Dominique Duleu, Sébastien Marcos, Pilar Karakas, Begum Geffard, Michel ScientificWorldJournal Review Article Since 2004, the anatomical distribution of vitamins in the monkey brain, studied using immunohistochemical techniques and new tools (specific antisera that discriminate different vitamins reasonably well), has been an ongoing research field. The visualization of immunoreactive structures containing vitamins (folic acid, riboflavin, thiamine, pyridoxal, and vitamin C) has recently been reported in the monkey brain (Macaca fascicularis), all these vitamins showing a restricted or very restricted distribution. Folic acid, thiamine, and riboflavin have only been observed in immunoreactive fibers, vitamin C has only been found in cell bodies (located in the primary somatosensory cortex), and pyridoxal has been found in both fibers and cell bodies. Perikarya containing pyridoxal have been observed in the paraventricular hypothalamic nucleus, the periventricular hypothalamic region, and in the supraoptic nucleus. The fibers containing vitamins are thick, smooth (without varicosities), and are of medium length or long, whereas immunoreactive cell bodies containing vitamins are round or triangular. At present, there are insufficient data to elucidate the roles played by vitamins in the brain, but the anatomical distribution of these compounds in the monkey brain provides a general idea (although imprecise and requiring much more study) about the possible functional implications of these molecules. In this sense, here the possible functional roles played by vitamins are discussed. TheScientificWorldJOURNAL 2011-06-09 /pmc/articles/PMC5720100/ /pubmed/21666992 http://dx.doi.org/10.1100/tsw.2011.115 Text en Copyright © 2011 Rafael Coveñas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Coveñas, Rafael
Mangas, Arturo
Bodet, Dominique
Duleu, Sébastien
Marcos, Pilar
Karakas, Begum
Geffard, Michel
Frontiers in Vitamin Research: New Antibodies, New Data
title Frontiers in Vitamin Research: New Antibodies, New Data
title_full Frontiers in Vitamin Research: New Antibodies, New Data
title_fullStr Frontiers in Vitamin Research: New Antibodies, New Data
title_full_unstemmed Frontiers in Vitamin Research: New Antibodies, New Data
title_short Frontiers in Vitamin Research: New Antibodies, New Data
title_sort frontiers in vitamin research: new antibodies, new data
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720100/
https://www.ncbi.nlm.nih.gov/pubmed/21666992
http://dx.doi.org/10.1100/tsw.2011.115
work_keys_str_mv AT covenasrafael frontiersinvitaminresearchnewantibodiesnewdata
AT mangasarturo frontiersinvitaminresearchnewantibodiesnewdata
AT bodetdominique frontiersinvitaminresearchnewantibodiesnewdata
AT duleusebastien frontiersinvitaminresearchnewantibodiesnewdata
AT marcospilar frontiersinvitaminresearchnewantibodiesnewdata
AT karakasbegum frontiersinvitaminresearchnewantibodiesnewdata
AT geffardmichel frontiersinvitaminresearchnewantibodiesnewdata