Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

We present the case of a 28-year-old man who presented with chest pain and elevated cardiac biomarkers, with no evidence of acute ischaemia. He had a pronounced eosinophilia, abnormal echocardiographic, cardiac MRI and CT findings. He underwent transbronchial biopsy of carinal lymph nodes and of lun...

Descripción completa

Detalles Bibliográficos
Autores principales: Bluett, Ronan, McDonnell, David, O’Dowling, Claire, Vaughan, Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Rare Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720267/
https://www.ncbi.nlm.nih.gov/pubmed/29170172
http://dx.doi.org/10.1136/bcr-2017-221227
_version_ 1783284634992246784
author Bluett, Ronan
McDonnell, David
O’Dowling, Claire
Vaughan, Carl
author_facet Bluett, Ronan
McDonnell, David
O’Dowling, Claire
Vaughan, Carl
author_sort Bluett, Ronan
collection PubMed
description We present the case of a 28-year-old man who presented with chest pain and elevated cardiac biomarkers, with no evidence of acute ischaemia. He had a pronounced eosinophilia, abnormal echocardiographic, cardiac MRI and CT findings. He underwent transbronchial biopsy of carinal lymph nodes and of lung parenchyma. Endomyocardial biopsy yielded an eosinophilic infiltrate. He was treated with high dose glucocorticoids and made a rapid recovery. Testing for FIP1L1-PDGFRA and other BCR-ABL1 mutations was negative. Ultimately, he was diagnosed with eosinophilic granulomatosis with polyangiitis, also known as Churg-Strauss syndrome.
format Online
Article
Text
id pubmed-5720267
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-57202672017-12-08 Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) Bluett, Ronan McDonnell, David O’Dowling, Claire Vaughan, Carl BMJ Case Rep Rare Disease We present the case of a 28-year-old man who presented with chest pain and elevated cardiac biomarkers, with no evidence of acute ischaemia. He had a pronounced eosinophilia, abnormal echocardiographic, cardiac MRI and CT findings. He underwent transbronchial biopsy of carinal lymph nodes and of lung parenchyma. Endomyocardial biopsy yielded an eosinophilic infiltrate. He was treated with high dose glucocorticoids and made a rapid recovery. Testing for FIP1L1-PDGFRA and other BCR-ABL1 mutations was negative. Ultimately, he was diagnosed with eosinophilic granulomatosis with polyangiitis, also known as Churg-Strauss syndrome. BMJ Publishing Group 2017-11-23 /pmc/articles/PMC5720267/ /pubmed/29170172 http://dx.doi.org/10.1136/bcr-2017-221227 Text en © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Rare Disease
Bluett, Ronan
McDonnell, David
O’Dowling, Claire
Vaughan, Carl
Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
title Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
title_full Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
title_fullStr Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
title_full_unstemmed Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
title_short Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)
title_sort eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (churg-strauss syndrome)
topic Rare Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720267/
https://www.ncbi.nlm.nih.gov/pubmed/29170172
http://dx.doi.org/10.1136/bcr-2017-221227
work_keys_str_mv AT bluettronan eosinophilicmyocarditisasafirstpresentationofeosinophilicgranulomatosiswithpolyangiitischurgstrausssyndrome
AT mcdonnelldavid eosinophilicmyocarditisasafirstpresentationofeosinophilicgranulomatosiswithpolyangiitischurgstrausssyndrome
AT odowlingclaire eosinophilicmyocarditisasafirstpresentationofeosinophilicgranulomatosiswithpolyangiitischurgstrausssyndrome
AT vaughancarl eosinophilicmyocarditisasafirstpresentationofeosinophilicgranulomatosiswithpolyangiitischurgstrausssyndrome

Ejemplares similares