Cargando…

Dysosmia and dysgeusia associated with duloxetine

Common adverse effects of serotonin–norepinephrine reuptake inhibitors are nausea, dry mouth, dizziness and headache. We describe the case of a patient with dysosmia and subsequent dysgeusia associated with duloxetine. A 68-year-old Japanese woman with a history of type 1 diabetes mellitus, hyperten...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshida, Katsuyuki, Fukuchi, Takahiko, Sugawara, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720271/
https://www.ncbi.nlm.nih.gov/pubmed/29170185
http://dx.doi.org/10.1136/bcr-2017-222470
_version_ 1783284635233419264
author Yoshida, Katsuyuki
Fukuchi, Takahiko
Sugawara, Hitoshi
author_facet Yoshida, Katsuyuki
Fukuchi, Takahiko
Sugawara, Hitoshi
author_sort Yoshida, Katsuyuki
collection PubMed
description Common adverse effects of serotonin–norepinephrine reuptake inhibitors are nausea, dry mouth, dizziness and headache. We describe the case of a patient with dysosmia and subsequent dysgeusia associated with duloxetine. A 68-year-old Japanese woman with a history of type 1 diabetes mellitus, hypertension, insomnia and reflux esophagitis presented to a local hospital with bilateral leg pain; she was treated with duloxetine. However, after 4 weeks, she sensed rotten egg smell, experienced nausea and vomiting and was admitted to our hospital. We diagnosed dysosmia using the T&T olfactometer threshold test and dysgeusia using filter paper disk method. Taste was assessed using electrogustometry. We suspected that dysosmia and dysgeusia were adverse effects of duloxetine. After stopping duloxetine, her symptoms gradually subsided and the above test results improved, despite continuing the other ongoing medication. To the best of our knowledge, this is the first case report of dysosmia and dysgeusia associated with duloxetine.
format Online
Article
Text
id pubmed-5720271
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-57202712017-12-08 Dysosmia and dysgeusia associated with duloxetine Yoshida, Katsuyuki Fukuchi, Takahiko Sugawara, Hitoshi BMJ Case Rep Case Report Common adverse effects of serotonin–norepinephrine reuptake inhibitors are nausea, dry mouth, dizziness and headache. We describe the case of a patient with dysosmia and subsequent dysgeusia associated with duloxetine. A 68-year-old Japanese woman with a history of type 1 diabetes mellitus, hypertension, insomnia and reflux esophagitis presented to a local hospital with bilateral leg pain; she was treated with duloxetine. However, after 4 weeks, she sensed rotten egg smell, experienced nausea and vomiting and was admitted to our hospital. We diagnosed dysosmia using the T&T olfactometer threshold test and dysgeusia using filter paper disk method. Taste was assessed using electrogustometry. We suspected that dysosmia and dysgeusia were adverse effects of duloxetine. After stopping duloxetine, her symptoms gradually subsided and the above test results improved, despite continuing the other ongoing medication. To the best of our knowledge, this is the first case report of dysosmia and dysgeusia associated with duloxetine. BMJ Publishing Group 2017-11-23 /pmc/articles/PMC5720271/ /pubmed/29170185 http://dx.doi.org/10.1136/bcr-2017-222470 Text en © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
spellingShingle Case Report
Yoshida, Katsuyuki
Fukuchi, Takahiko
Sugawara, Hitoshi
Dysosmia and dysgeusia associated with duloxetine
title Dysosmia and dysgeusia associated with duloxetine
title_full Dysosmia and dysgeusia associated with duloxetine
title_fullStr Dysosmia and dysgeusia associated with duloxetine
title_full_unstemmed Dysosmia and dysgeusia associated with duloxetine
title_short Dysosmia and dysgeusia associated with duloxetine
title_sort dysosmia and dysgeusia associated with duloxetine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720271/
https://www.ncbi.nlm.nih.gov/pubmed/29170185
http://dx.doi.org/10.1136/bcr-2017-222470
work_keys_str_mv AT yoshidakatsuyuki dysosmiaanddysgeusiaassociatedwithduloxetine
AT fukuchitakahiko dysosmiaanddysgeusiaassociatedwithduloxetine
AT sugawarahitoshi dysosmiaanddysgeusiaassociatedwithduloxetine