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Dysosmia and dysgeusia associated with duloxetine
Common adverse effects of serotonin–norepinephrine reuptake inhibitors are nausea, dry mouth, dizziness and headache. We describe the case of a patient with dysosmia and subsequent dysgeusia associated with duloxetine. A 68-year-old Japanese woman with a history of type 1 diabetes mellitus, hyperten...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720271/ https://www.ncbi.nlm.nih.gov/pubmed/29170185 http://dx.doi.org/10.1136/bcr-2017-222470 |
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author | Yoshida, Katsuyuki Fukuchi, Takahiko Sugawara, Hitoshi |
author_facet | Yoshida, Katsuyuki Fukuchi, Takahiko Sugawara, Hitoshi |
author_sort | Yoshida, Katsuyuki |
collection | PubMed |
description | Common adverse effects of serotonin–norepinephrine reuptake inhibitors are nausea, dry mouth, dizziness and headache. We describe the case of a patient with dysosmia and subsequent dysgeusia associated with duloxetine. A 68-year-old Japanese woman with a history of type 1 diabetes mellitus, hypertension, insomnia and reflux esophagitis presented to a local hospital with bilateral leg pain; she was treated with duloxetine. However, after 4 weeks, she sensed rotten egg smell, experienced nausea and vomiting and was admitted to our hospital. We diagnosed dysosmia using the T&T olfactometer threshold test and dysgeusia using filter paper disk method. Taste was assessed using electrogustometry. We suspected that dysosmia and dysgeusia were adverse effects of duloxetine. After stopping duloxetine, her symptoms gradually subsided and the above test results improved, despite continuing the other ongoing medication. To the best of our knowledge, this is the first case report of dysosmia and dysgeusia associated with duloxetine. |
format | Online Article Text |
id | pubmed-5720271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-57202712017-12-08 Dysosmia and dysgeusia associated with duloxetine Yoshida, Katsuyuki Fukuchi, Takahiko Sugawara, Hitoshi BMJ Case Rep Case Report Common adverse effects of serotonin–norepinephrine reuptake inhibitors are nausea, dry mouth, dizziness and headache. We describe the case of a patient with dysosmia and subsequent dysgeusia associated with duloxetine. A 68-year-old Japanese woman with a history of type 1 diabetes mellitus, hypertension, insomnia and reflux esophagitis presented to a local hospital with bilateral leg pain; she was treated with duloxetine. However, after 4 weeks, she sensed rotten egg smell, experienced nausea and vomiting and was admitted to our hospital. We diagnosed dysosmia using the T&T olfactometer threshold test and dysgeusia using filter paper disk method. Taste was assessed using electrogustometry. We suspected that dysosmia and dysgeusia were adverse effects of duloxetine. After stopping duloxetine, her symptoms gradually subsided and the above test results improved, despite continuing the other ongoing medication. To the best of our knowledge, this is the first case report of dysosmia and dysgeusia associated with duloxetine. BMJ Publishing Group 2017-11-23 /pmc/articles/PMC5720271/ /pubmed/29170185 http://dx.doi.org/10.1136/bcr-2017-222470 Text en © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Case Report Yoshida, Katsuyuki Fukuchi, Takahiko Sugawara, Hitoshi Dysosmia and dysgeusia associated with duloxetine |
title | Dysosmia and dysgeusia associated with duloxetine |
title_full | Dysosmia and dysgeusia associated with duloxetine |
title_fullStr | Dysosmia and dysgeusia associated with duloxetine |
title_full_unstemmed | Dysosmia and dysgeusia associated with duloxetine |
title_short | Dysosmia and dysgeusia associated with duloxetine |
title_sort | dysosmia and dysgeusia associated with duloxetine |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720271/ https://www.ncbi.nlm.nih.gov/pubmed/29170185 http://dx.doi.org/10.1136/bcr-2017-222470 |
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