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Myc Cooperates with Ras by Programming Inflammation and Immune Suppression

The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRas(G12D)-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by hi...

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Detalles Bibliográficos
Autores principales:	Kortlever, Roderik M., Sodir, Nicole M., Wilson, Catherine H., Burkhart, Deborah L., Pellegrinet, Luca, Brown Swigart, Lamorna, Littlewood, Trevor D., Evan, Gerard I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720393/ https://www.ncbi.nlm.nih.gov/pubmed/29195074 http://dx.doi.org/10.1016/j.cell.2017.11.013

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