Cargando…

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity

The mammalian circadian clock and the cell cycle are two major biological oscillators whose coupling influences cell fate decisions. In the present study, we use a model-driven experimental approach to investigate the interplay between clock and cell cycle components and the dysregulatory effects of...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Athman, Rukeia, Genov, Nikolai N., Mazuch, Jeannine, Zhang, Kaiyang, Yu, Yong, Fuhr, Luise, Abreu, Mónica, Li, Yin, Wallach, Thomas, Kramer, Achim, Schmitt, Clemens A., Relógio, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720494/ https://www.ncbi.nlm.nih.gov/pubmed/29216180 http://dx.doi.org/10.1371/journal.pbio.2002940

Ejemplares similares

A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer
por: El-Athman, Rukeia, et al.
Publicado: (2018)

A Computational Analysis of Alternative Splicing across Mammalian Tissues Reveals Circadian and Ultradian Rhythms in Splicing Events
por: El-Athman, Rukeia, et al.
Publicado: (2019)

The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes
por: Fuhr, Luise, et al.
Publicado: (2019)

The reciprocal interplay between TNFα and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells
por: Abreu, Mónica, et al.
Publicado: (2018)

The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer
por: Fuhr, Luise, et al.
Publicado: (2018)

Ras-Mediated Deregulation of the Circadian Clock in Cancer
por: Relógio, Angela, et al.
Publicado: (2014)

Assembly of a Comprehensive Regulatory Network for the Mammalian Circadian Clock: A Bioinformatics Approach
por: Lehmann, Robert, et al.
Publicado: (2015)

Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock
por: Fuhr, Luise, et al.
Publicado: (2022)

Tuning the Mammalian Circadian Clock: Robust Synergy of Two Loops
por: Relógio, Angela, et al.
Publicado: (2011)

Analysis of the Circadian Regulation of Cancer Hallmarks by a Cross-Platform Study of Colorectal Cancer Time-Series Data Reveals an Association with Genes Involved in Huntington’s Disease
por: Yalçin, Müge, et al.
Publicado: (2020)

Circadian systems biology: When time matters
por: Fuhr, Luise, et al.
Publicado: (2015)

New insights on the regulation of INK4/ARF locus expression
por: Gamell, Cristina, et al.
Publicado: (2017)

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line
por: Genov, Nikolai, et al.
Publicado: (2019)

Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms
por: Farooq, Umer, et al.
Publicado: (2022)

Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day
por: Basti, Alireza, et al.
Publicado: (2021)

Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression
por: Ming, Zizhen, et al.
Publicado: (2020)

MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence
por: Culerrier, Raphaël, et al.
Publicado: (2016)

Temporal Splicing Switches in Elements of the TNF-Pathway Identified by Computational Analysis of Transcriptome Data for Human Cell Lines
por: Genov, Nikolai, et al.
Publicado: (2019)

Differential expression of the circadian clock network correlates with tumour progression in gliomas
por: Petkovic, Marina, et al.
Publicado: (2023)

Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence
por: Agherbi, Hanane, et al.
Publicado: (2009)

Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions
por: Salas, Elisabet, et al.
Publicado: (2014)

An interdependent network of functional enhancers regulates transcription and EZH2 loading at the INK4a/ARF locus
por: Farooq, Umer, et al.
Publicado: (2021)

Corrigendum: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
por: Bracken, Adrian P., et al.
Publicado: (2023)

Sex and age-dependent characterization of the circadian clock as a potential biomarker for physical performance: A prospective study protocol
por: Yalçin, Müge, et al.
Publicado: (2023)

Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity
por: Klemz, Sabrina, et al.
Publicado: (2021)

Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus
por: De Jaime-Soguero, Anchel, et al.
Publicado: (2017)

Molecular characterization of the circadian clock in paediatric leukaemia patients: a prospective study protocol
por: Ludwig, Marius, et al.
Publicado: (2023)

Functional characterization of the circadian clock in the Antarctic krill, Euphausia superba
por: Biscontin, Alberto, et al.
Publicado: (2017)

Circadian clock-controlled diurnal oscillation of Ras/ERK signaling in mouse liver
por: TSUCHIYA, Yoshiki, et al.
Publicado: (2013)

The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction
por: Mazzoccoli, Gianluigi, et al.
Publicado: (2020)

A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer
por: Hesse, Janina, et al.
Publicado: (2021)

Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes
por: Castellana, Stefano, et al.
Publicado: (2018)

The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression
por: Vonlanthen, S, et al.
Publicado: (2001)

Emerging Roles for the INK4a/ARF (CDKN2A) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes
por: Kahoul, Yasmina, et al.
Publicado: (2020)

FLOWERING LOCUS C -dependent and -independent regulation of the circadian clock by the autonomous and vernalization pathways
por: Salathia, Neeraj, et al.
Publicado: (2006)

INK4a/ARF-dependent senescence upon persistent replication stress
por: O’Driscoll, Mark
Publicado: (2013)

INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice
por: Le, Oanh, et al.
Publicado: (2018)

HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss
por: Shin, Clifford H., et al.
Publicado: (2017)

Pancreatic Progenitor Commitment Is Marked by an Increase in Ink4a/Arf Expression
por: Montano, Elena, et al.
Publicado: (2021)

Regulation of Clock-Controlled Genes in Mammals
por: Bozek, Katarzyna, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_r2l5reimoukavbu3bu5lu1luim